| 双壳贝类麻痹性贝毒抗性机制的研究 |
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| 引用本文： | 崔伟民,杨维东,刘洁生.双壳贝类麻痹性贝毒抗性机制的研究[J].卫生研究,2008,37(3):377-380. |
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| 作者姓名： | 崔伟民 杨维东 刘洁生 |
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| 作者单位： | 暨南大学生物工程学系,广州,510632 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)
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广东省自然科学基金 |
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| 摘 要： | 麻痹性贝毒(PSP)是一类神经肌肉麻痹剂,可以阻断电压门控钠离子通道,造成神经系统传输障碍而产生麻痹作用。某些双贝壳类对PSP毒素具有耐受性和抗性,其抗性机制可能与代谢速率、生物转化和钠通道突变等有关,其中钠通道突变是双壳贝类对PSP毒素产生抗性的最重要的分子机制。
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| 关 键 词： | 麻痹性贝毒 水产品 神经系统 食物中毒 贝类 |
Studies on resistance mechanisms to paralytic shellfish poisoning in bivalves |
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| CUI Weimin,YANG Weidong,LIU Jiesheng.Studies on resistance mechanisms to paralytic shellfish poisoning in bivalves[J].Journal of Hygiene Research,2008,37(3):377-380. |
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| Authors: | CUI Weimin YANG Weidong LIU Jiesheng |
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| Institution: | Department of Biotechnology, Jinan University, Guangzhou 510632, China. |
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| Abstract: | Paralytic shellfish poisoning (PSP) toxins could be neuromuscular paralysis agents, which could blocke the voltage-gated sodium channels, and then could cause holdback in nervous system transmission. Some bivalves could be tolerant of PSP toxins. The resistance mechanisms might be related to metabolism, biotransformation and the mutation of voltage-gated sodium channels, etc., in which the mutation of sodium channels might be the most important molecular mechanism of the resistance mechanism of bivalves. |
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| Keywords: | paralytic shellfish poisoning resistance mechanism voltage-gated sodium channel |
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