| 河南省漯河地区乙型肝炎病毒基因型别的初步研究 |
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| 引用本文： | 王福青,黄小蕾,李爱琴,王建国,张福华,崔燕兵,伊瑶,陈斯勇.河南省漯河地区乙型肝炎病毒基因型别的初步研究[J].中华实验和临床病毒学杂志,2008,22(4). |
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| 作者姓名： | 王福青 黄小蕾 李爱琴 王建国 张福华 崔燕兵 伊瑶 陈斯勇 |
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| 作者单位： | 1. 462002,漯河医学高等专科学校
2. 中国疾病预防控制中心病毒病预防控制所 |
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| 摘 要： | 目的 初步确定流行于河南漯河地区的乙肝病毒的基因型的基本情况.方法 采集河南漯河地区乙型肝炎表面抗原阳性的血清,利用PCR扩增得到HBV的S基因;用DANSTAR软件对其进行核苷酸序列分析,构建系统发生树,分析基因型.结果约75.7%样本的HBV S基因序列位于HBV系统发生树的基因型C,约20%的样本其S基因位于系统发生树的基因型B,近4.3%的样本其S基因位于系统发生树的基因型D.结论 流行于河南漯河地区的乙肝病毒多数为基因型C,少数为基因型B,极少数为基因型D.
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| 关 键 词： | 肝炎病毒 乙型 基因型 |
Genotypes of hepatitis B virus in Henan Luohe area |
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| WANG Fu-qing,HUANG Xiao-lei,LI Ai-qin,WANG Jian-guo,ZHANG Fu-hua,CUI Yan-bing,YI Yao,CHEN SI-yong.Genotypes of hepatitis B virus in Henan Luohe area[J].Chinese Journal of Experimental and Clinical Virology,2008,22(4). |
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| Authors: | WANG Fu-qing HUANG Xiao-lei LI Ai-qin WANG Jian-guo ZHANG Fu-hua CUI Yan-bing YI Yao CHEN SI-yong |
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| Abstract: | Objective To determine the main genotype of hepatitis B virus(HBV) prevailed in Henan Luohe area. Methods Serum specimens were collected from 94 HBsAg positive individuals, and HBV S gene were obtained by PCR amplifying, and the gene sequences were analyzed and the polygenetic tree was drawn by the software MEGA3. Results About 75.7% samples of HBV S gene clustered in genotype C, about 20% samples clustered at genotype B in the HBV polygenetie tree, about 4.3% samples clustered at genotype D in the HBV pelygenetic tree. Conclusion The main genotype of hepatitis B virus prevalent in Henan Luohe is genotype C,genotype B is rarely seen, and genotype D is rarely seen. |
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| Keywords: | Hepatitis B virus Genotype |
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