Defective Human T-Cell Lymphotropic Virus Type I (HTLV-I) Provirus in 10 Chilean Seronegative Patients with Tropical Spastic Paraparesis or HTLV-I-Associated Myelopathy |
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| Authors: | Eugenio Ramirez Luis Cartier Maritza Rios and Jorge Fernandez |
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| Institution: | Section of Virology, Department of Health Laboratories, Public Health Institute of Chile,1. and Departments of Neurology2. and Microbiology,3. Faculty of Medicine, University of Chile, Santiago, Chile |
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| Abstract: | We studied the presence of tax and ltr genes from human T-cell lymphotropic virus type I (HTLV-I) provirus in the peripheral blood mononuclear cells from 15 seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy by PCR. Only a region of the tax gene from 10 patients was amplified. The nucleotide homologies of six Chilean isolates to the ATK-1 clone ranged between 98.7 and 99.4%. |
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