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肺癌靶向治疗新进展及展望
引用本文:洪少东,张 力.肺癌靶向治疗新进展及展望[J].中国癌症杂志,2020,30(10):733-743.
作者姓名:洪少东  张 力
作者单位:中山大学肿瘤防治中心内科,广东 广州 510060
摘    要:近年来,靶向药物治疗已全面改变了肺癌的诊疗模式,并显著地改善了肺癌患者的生存期和生活质量。药物的更新迭代、靶向治疗模式的优化、耐药机制的探索、新靶点新药物的研发,不断地丰富肺癌靶向治疗的内容。针对驱动基因阳性肺癌的靶向治疗最新进展和未来方向进行综述。

关 键 词:肺癌  驱动基因  靶向治疗  耐药  

Recent advances and prospect in targeted therapy for lung cancer
HONG Shaodong,ZHANG Li.Recent advances and prospect in targeted therapy for lung cancer[J].China Oncology,2020,30(10):733-743.
Authors:HONG Shaodong  ZHANG Li
Institution:Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong Province, China;
Abstract:During the past years, targeted agents have dramatically changed the diagnosis and treatment paradigm of lung cancer,which also have significantly improved the survival and quality of life for patients with lung cancer. With the innovations of targetedagents, the optimization of modes of targeted treatment, the exploration of mechanisms of drug resistance and the research anddevelopment of novel targets and drugs, the context of targeted therapy in lung cancer is largely enriched. In this paper, we discussedthe recent advances and future direction of targeted therapy for driver mutation positive lung cancer.
Keywords:Lung cancer  Driver gene  Targeted therapy  Drug resistance  
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