盐酸羟考酮缓释片和盐酸吗啡注射液控制胰腺癌晚期癌痛的效果分析

目的:探讨盐酸羟考酮缓释片联合盐酸吗啡注射液控制胰腺癌晚期癌痛的效果。方法:选取我院2015年1月至2017年12月确诊的60例晚期胰腺癌患者，采用随机数字表法分为研究组和对照组各30例，研究组采用盐酸羟考酮缓释片联合盐酸吗啡注射液滴定，对照组采用盐酸吗啡注射液滴定；记录两组患者完成滴定所需的平均时间、疼痛控制情况、滴定治疗前与治疗后的血清前列腺素E2（PGE2）、5-羟色胺（5-HT）、组胺（HIS）、血浆P物质（SP）、β内啡肽（β-EP）及用药过程中的不良反应。结果:研究组在7天内完成盐酸吗啡注射液滴定的时间短于对照组，差异具有统计学意义（P＜0.05）；治疗7天后，研究组的疼痛控制效果优于对照组，差异具有统计学意义（P＜0.05）；治疗前，研究组和对照组的血清PGE2、5-HT、HIS、血浆SP、血浆β-EP差异不具有统计学意义（P＞0.05）；治疗后，研究组患者的血清PGE2、5-HT、HIS、血浆SP低于对照组（P＜0.05），研究组的血浆β-EP高于对照组（P＜0.05）；研究组的不良反应发生率（30.00%）与对照组（13.33%）比较，差异不具有统计学意义（P＞0.05）。结论:盐酸羟考酮缓释片联合盐酸吗啡注射液控制胰腺癌晚期癌痛效果优于单用盐酸吗啡注射液，可显著减低疼痛相关因子PGE2、5-HT、HIS、血浆SP水平。

Effect of oxycodone hydrochloride sustained-release tablets and morphine hydrochloride injection on advanced cancer pain in pancreatic cancer

Objective:To investigate the effect of oxycodone hydrochloride sustained-release tablets combined with morphine hydrochloride injection on the control of advanced cancer pain in pancreatic cancer.Methods:Sixty patients with advanced pancreatic cancer diagnosed in our hospital from January 2015 to December 2017 were randomly divided into the study group and the control group by 30 patients.The study group used oxycodone hydrochloride sustained-release tablets combined with morphine hydrochloride.The injection was titrated,and the control group was treated with morphine hydrochloride injection.The average time required for the two groups to complete the titration,pain control,serum prostaglandin E2 (PGE2) and serotonin (5-HT),histamine (HIS),plasma substance P (SP),beta-endorphin (β-EP),and adverse reactions during drug administration were recorded.Results:The time of completion of morphine hydrochloride injection in the study group was shorter than that in the control group within 7 days,and the difference was statistically significant (P＜0.05).After 7 days of treatment,the pain control effect of the study group was better than that of the control group,and the difference was statistically significant (P＜0.05).Before treatment,there was no significant difference in serum PGE2,5-HT,HIS,plasma SP and plasma β-EP between the study group and the control group (P＞0.05).After treatment,the serum PGE2,5-HT,HIS and plasma SP of the study group patients were lower than the control (P＜0.05).The plasma β-EP of the study group was higher than that of the control group (P＜0.05).The incidence of adverse reactions in the study group was 30.00% and that of the control group was 13.33%.The difference was not statistically significant (P＞0.05).Conclusion:The effect of oxycodone hydrochloride sustained-release tablets combined with morphine hydrochloride injection on the control of advanced cancer pain in pancreatic cancer is better than that of morphine hydrochloride alone,which can significantly reduce the pain-related factors PGE2,5-HT,HIS and plasma SP.