| STAT1表达对高级别浆液性卵巢癌患者生存的影响分析 |
| |
| 引用本文： | 李 玮1,张 静2,朱根海1,吴秀荣1. STAT1表达对高级别浆液性卵巢癌患者生存的影响分析[J]. 现代肿瘤医学, 2020, 0(9): 1539-1542. DOI: 10.3969/j.issn.1672-4992.2020.09.026 |
| |
| 作者姓名： | 李 玮1 张 静2 朱根海1 吴秀荣1 |
| |
| 作者单位： | 1.海南省人民医院妇科，海南 海口 570000；2.陕西中医药大学第二附属医院妇科，陕西 咸阳 712000 |
| |
| 摘 要： | 目的:探讨STAT1在高级别浆液性卵巢癌（HGSC）组织中的表达特点及其与预后的关系。方法:选取我院2005年1月至2015年1月106例HGSC患者病理活检组织标本构建组织微阵列，采用免疫组织化学染色法检测所有活检组织标本中STAT1的表达情况，分析STAT1表达对HGSC患者总体生存期（OS）的影响。结果:在HGSC中STAT1的高表达与高OS显著相关（P=0.013）。Cox比例风险回归模型显示，STAT1表达、FIGO分期和细胞减灭术状态对HGSC患者OS均有独立影响。结论:STAT1高表达与HGSC患者更高的OS存在显著相关性，可以作为预后判断的生物学标志物。
|
| 关 键 词： | 高级别浆液性卵巢癌 STAT1 预后因子 总体生存率 免疫组织化学 |
Clinical significance of STAT1 expression in high grade serous ovarian cancer |
| |
| Li Wei1,Zhang Jing2,Zhu Genhai1,Wu Xiurong1. Clinical significance of STAT1 expression in high grade serous ovarian cancer[J]. Journal of Modern Oncology, 2020, 0(9): 1539-1542. DOI: 10.3969/j.issn.1672-4992.2020.09.026 |
| |
| Authors: | Li Wei1 Zhang Jing2 Zhu Genhai1 Wu Xiurong1 |
| |
| Affiliation: | 1.Department of Gynecology，Hainan Provincial People's Hospital，Hainan Haikou 570000，China；2.Department of Gynecology，the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine，Shaanxi Xianyang 712000，China. |
| |
| Abstract: | Objective:To investigate the relationship of STAT1 expression characteristics with clinical prognosis in the high grade serous ovarian cancer (HGSC).Methods:Expression of STAT1 was determined with immunohistochemical staining of a tissue microarray in 106 specimens of HGSC.The relationship of STAT1 expression levels with prognosis of HGSC patients was analyzed.Results:Kaplan-Meier survival analysis demonstrated that patients with high STAT1 expression was significantly associated with improved overall survival(P=0.013).Proportional hazards regression Cox models showed STAT1 expression，FIGO stage and cytoreduction had independent effect on overall survival.Conclusion:High STAT1 expression is associated with improved overall survival in HGSC and may serve as a prognostic marker. |
| |
| Keywords: | HGSC STAT1 prognostic factor overall survival immunohistochemistry |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
