Tim-3调控巨噬细胞极化在类风湿性关节炎中的研究进展

类风湿性关节炎(RA)是由自身免疫功能紊乱导致的慢性难治性疾病,T细胞被持续活化并长期处于高反应的状态是其免疫反应的重要环节。T细胞免疫球蛋白黏蛋白分子-3(Tim-3)是在免疫系统的各种类型细胞上表达的表面分子,其信号传导可以增强或抑制巨噬细胞的免疫反应。越来越多的研究表明,Tim-3在免疫系统中具有关键作用,可调控巨噬细胞极化,促进各种细胞内信号传导和免疫反应,在RA病理过程中具有重要意义。本文综述近年来关于Tim-3调控巨噬细胞极化在RA中的相关研究进展,为治疗RA提供新的思路。

Research progress of Tim-3 regulating the polarization of macrophage in rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic and refractory disease caused by autoimmune dysfunction. The continuous activation and the status of long-term high response of T cells are important links of its immune response. T cell immunoglobulin and mucin-domain-containing molecule-3 (Tim-3) is a surface molecule expressed on various cell types of immune system, and its signal transduction can enhance or inhibit the immune response of macrophages. A large number of studies have indicated that Tim-3 plays an important role in the immune system, such as regulating the polarization of macrophage, promoting the transduction of various intracellular signal and immune responses and playing a key role in the pathogenesis of RA. Therefore, the paper reviews the relevant research progress on Tim-3 regulating the polarization of macrophage in RA in recent years and provides new ideas for deepening the treatment of RA.