| 2017-2018年成都地区诺如病毒聚集性疫情病原基因型分析 |
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| 引用本文： | 程悦,孟建彤,陈恒,付芮,黄薇,梁娴. 2017-2018年成都地区诺如病毒聚集性疫情病原基因型分析[J]. 实用预防医学, 2020, 27(3): 311-314. DOI: 10.3969/j.issn.1006-3110.2020.03.014 |
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| 作者姓名： | 程悦 孟建彤 陈恒 付芮 黄薇 梁娴 |
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| 作者单位： | 1.成都市疾病预防控制中心,四川 成都 610041;2.成都中医药大学,四川 成都 610075 |
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| 基金项目： | 四川省卫生计生委重点项目(17ZD046);成都市卫生和计划生育委员会项目(2017015) |
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| 摘 要： | 目的分析2017-2018年成都地区诺如病毒聚集性疫情中病毒基因型构成情况,为疾病防控工作提供依据。方法选取2017-2018年诺如病毒聚集性疫情标本,对病毒基因RdRp及VP1区片段测序,构建进化树并进行同源性分析。结果测序结果显示,68份肛拭子标本中16.2%(11/68)为GⅠ群(包括GⅠ.2、GⅠ.3和GⅠ.5型),83.8%(57/68)为GⅡ群(包括GⅡ.P16-GⅡ.2、GⅡ.P17-GⅡ.17、GⅡ.P8-GⅡ.8、GⅡ.P12-GⅡ.3、GⅡ.P7-GⅡ.6和GⅡ.P15-GⅡ.15型)。2017年以GⅡ.P16-GⅡ.2型为主;2018年GⅠ群及GⅡ.P17-GⅡ.17型均显著增加,同时检出其他4种基因型。各基因型病毒变异不明显,核苷酸同源性为93.4%~100%。结论2018年成都地区诺如病毒流行株基因型构成较2017年复杂,可能与聚集性疫情增长有关。应持续监测诺如病毒基因型流行情况,及时掌握病毒变异动态,以期提高疾病防控的预警能力。
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| 关 键 词： | 诺如病毒 基因型 聚集性疫情 |
| 收稿时间： | 2019-04-18 |
Viral genotype analysis of aggregation epidemics induced by norovirus infection in Chengdu region, 2017-2018 |
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| CHENG Yue,MENG Jian-tong,CHEN Heng,FU Rui,HUANG Wei,LIANG Xian. Viral genotype analysis of aggregation epidemics induced by norovirus infection in Chengdu region, 2017-2018[J]. Practical Preventive Medicine, 2020, 27(3): 311-314. DOI: 10.3969/j.issn.1006-3110.2020.03.014 |
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| Authors: | CHENG Yue MENG Jian-tong CHEN Heng FU Rui HUANG Wei LIANG Xian |
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| Affiliation: | 1. Chengdu Municipal Center for Disease Control and Prevention, Chengdu, Sichuan 610041, China;2. Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China |
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| Abstract: | Objective To analyze the composition of viral genotypes in aggregation epidemics induced by norovirus infection in Chengdu region in 2017-2018, and to provide a basis for its prevention and control. Methods Anal swab samples from aggregation epidemics induced by norovirus infection in Chengdu region during 2017-2018 were selected, and then the sequence information of RdRp and VP1 was analyzed. The phylogenetic tree was constructed to analyze the nucleotide sequence homology. Results The sequence analysis revealed that 16.2% (11/68) samples belonged to NoV genogroup GI (including GI.2, GI.3 and GI.5). 83.8% (57/68) samples belonged to NoV genogroup GII (including GII.P16-GII.2, GII.P17-GII.17, GII.P8-GII.8, GII.P12-GII.3, GII.P7-GII.6 and GII.P15-GII.15). GII.P16-GII.2 was the main genotype circulating in 2017. Genogroups GI and GII.P17-GII.17 significantly prevailed in 2018; meanwhile, other four genotypes were detected. The variation of noroviruses with different genotypes was not obvious. The nucleotide sequence homology ranged from 93.4% to 100%. Conclusions The genotype composition of norovirus strains predominated in Chengdu region in 2018 was more complicated than that in 2017, which might be related to the increase of aggregation epidemics. It is necessary to continuously monitor the molecular epidemiology of norovirus strains and master the variation of norovirus in time so as to improve the early warning ability in disease prevention and control. |
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| Keywords: | norovirus genotype aggregation epidemic |
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