NP方案联合微波消融治疗晚期非小细胞肺癌疗效及对血清SCC、CEA、CYFRA21-1水平的影响

目的:探讨NP方案（长春瑞滨联合顺铂化疗方案）联合微波消融治疗晚期非小细胞肺癌疗效及对血清SCC、CEA、CYFRA21-1水平的影响。方法:选取76例晚期非小细胞肺癌患者，按照治疗方式的不同分为研究组（NP化疗方案联合微波消融，42例）和对照组（NP化疗方案，34例）。观察并比较两组患者近期疗效、生活质量、预后（治疗后1年生存率、复发率）、不良反应发生率及治疗前后血清SCC、CEA、CYFRA21-1水平的变化。结果:近期疗效:研究组治疗总有效率为69.05%（29/42），高于对照组的35.29%（12/34），差异显著（P<0.05）。生活质量:治疗后，研究组患者认知功能、社会功能等五个维度的评分均显著高于对照组（均P<0.05）。预后:研究组患者治疗后1年生存率为57.14%，显著高于对照组的32.35%（P<0.05）；研究组治疗后1年复发率为64.29%，显著低于对照组的88.24%（P<0.05）。不良反应发生率:两组患者发热、胃肠道反应、骨髓抑制、肝功能损害、肾功能损害等不良反应发生率的差异均无统计学意义（均P>0.05）。血清因子:两组患者治疗后血清SCC、CEA、CYFRA21-1水平均低于治疗前（均P<0.05），且研究组上述指标均低于对照组（均P<0.05）。结论:NP化疗方案联合微波消融治疗晚期非小细胞肺癌的疗效显著，可显著提高患者的生活质量，并能提高患者术后1年生存率、降低复发率，并未增加不良反应发生率，且能有效调节相关血清因子水平，效果优于单纯NP化疗，值得推广应用。

Effect of NP regimen combined with microwave ablation on advanced non-small cell lung cancer and its effect on serum SCC，CEA and CYFRA21-1 levels

Objective:To investigate the effect of NP regimen(vinorelbine combined with cisplatin chemotherapy) combined with microwave ablation on advanced non-small cell lung cancer and its effect on serum SCC，CEA and CYFRA21-1 levels.Methods:76 patients with advanced non-small cell lung cancer were enrolled.The patients were divided into study group(NP chemotherapy regimen combined with microwave ablation，42 patients) and control group(NP chemotherapy regimen，34 patients).The short-term efficacy，quality of life，prognosis(1-year survival rate after treatment，recurrence rate)，incidence of adverse reactions，and changes of serum SCC，CEA，and CYFRA21-1 levels before and after treatment of the two groups were observed and compared.Results:Short-term efficacy showed that the total effective rate of the study group was 69.05%(29/42)，which was higher than 35.29%（12/34） of the control group，and the difference was statistically significant(P<0.05).Quality of life showed that after treatment，the scores of the five dimensions，such as the cognitive function，social function score of the study group were significantly higher than the scores of the control group(all P<0.05).The 1-year survival rate after treatment of the study group was 57.14%，which was significantly higher than 32.35% of the control group(P<0.05).The 1-year recurrence rate after treatment of the study group was 64.29%，which was significantly lower than 88.24% of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions such as fever，gastrointestinal reactions，myelosuppression，liver function damage，and renal function damage between the two groups(all P>0.05).After treatment，the levels of serum SCC，CEA，and CYFRA21-1 were lower in the two groups than before treatment(P<0.05)，and the above indexes in the study group were lower than those in the control group (all P<0.05).Conclusion:NP chemotherapy combined with microwave ablation is effective in the treatment of advanced non-small cell lung cancer，which can significantly improve the quality of life of patients，improve the 1-year survival rate and reduce the recurrence rate without increasing the incidence of adverse reactions.It can effectively regulate the level of related serum factors，and the effect is better than NP chemotherapy，which is worthy of popularization and application.