| 炎症相关细胞因子在弥漫大B细胞淋巴瘤中作用的研究进展 |
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| 引用本文： | 包雪娇,王树叶.炎症相关细胞因子在弥漫大B细胞淋巴瘤中作用的研究进展[J].现代肿瘤医学,2020,0(12):2141-2145. |
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| 作者姓名： | 包雪娇 王树叶 |
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| 作者单位： | 哈尔滨医科大学附属第一医院血液内科，黑龙江 哈尔滨 150001 |
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| 基金项目： | 国家重点基础研究发展计划子课题(编号:2012CBA01303) |
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| 摘 要： | IL-6由肿瘤细胞自分泌，与肿瘤侵袭性密切相关；TNF-α在机体肿瘤免疫应答中起到了重要作用，可引起肿瘤细胞坏死，且可诱导IL-6的表达；IFN-γ具有抗病毒，抗肿瘤和免疫调控的作用；IL-10 具有双向免疫调节作用，在肿瘤环境中对免疫应答具有负向调节作用，同时也能发挥刺激作用。上述细胞因子在弥漫大B细胞淋巴瘤（diffuse large B cell lymphoma,DLBCL）的发生发展中或起到协同作用，并可能作为DLBCL诊断及预后的指标。
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| 关 键 词： | 弥漫大B细胞淋巴瘤 白细胞介素-6 肿瘤坏死因子-α 干扰素-γ 白细胞介素-10 肿瘤微环境 |
Research progress of role of inflammation related cytokines in diffuse large B-cell lymphoma |
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| Bao Xuejiao,Wang Shuye.Research progress of role of inflammation related cytokines in diffuse large B-cell lymphoma[J].Journal of Modern Oncology,2020,0(12):2141-2145. |
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| Authors: | Bao Xuejiao Wang Shuye |
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| Institution: | Department of Hematology,First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150001,China. |
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| Abstract: | IL-6 is autocrine by tumor cells and is closely related to tumor invasion.TNF-α plays an important role in tumor immune response,which can cause tumor cell necrosis and induce IL-6 expression.IFN-γ has anti-virus,anti-tumor and immune regulation.IL-10 has a two-way immunomodulatory effect,which has a negative regulatory effect on the immune response in the tumor environment,and can also exert a stimulating effect.The above cytokines may play a synergistic role in the development of diffuse large B cell lymphoma (DLBCL) and may serve as an indicator for the diagnosis and prognosis of DLBCL. |
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| Keywords: | diffuse large B-cell lymphoma interleukin-6 tumor necrosis factor-α interferon-γ interleukin-10 tumor microenvironment |
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