首次发作抑郁症患者静息态fMRI低频振幅的初步研究

目的 探讨首次发作抑郁症患者脑区静息态功能磁共振成像（rs-fMRI）的低频振幅（ALFF）值和低频振幅比率（fALFF）的变化，并分析17项汉密尔顿抑郁量表（HAMD-17）评分与ALFF、fALFF异常脑区的相关性。 方法 选取2019年1月至12月就诊于苏州大学附属广济医院的首发抑郁症患者17例（抑郁症组:男性5例、女性12例，年龄19~54岁）和17名正常志愿者（正常对照组:男性8名、女性9名，年龄20~58岁），收集两组受试者的人口学资料以及HAMD-17评分并进行回顾性分析，所有受试者均行rs-fMRI扫描。基于MATLAB R2017a平台，采用ALFF和fALFF方法对rs-fMRI数据分析，比较2组受试者的ALFF值和fALFF，提取2组受试者差异有统计学意义的脑区。2组计量资料的比较采用两独立样本t检验，对脑区的ALFF值和fALFF分别与HAMD-17评分行Pearson相关性分析。 结果 与正常对照组相比，抑郁症组患者右前扣带回（0.51±0.11对0.76±0.12）、右前扣带回和旁扣带回（0.56±0.08对0.77±0.16）的ALFF值降低，差异有统计学意义（t=?7.08、?4.56，均P<0.05），右前扣带回的fALFF降低（0.96±0.06对1.04±0.05）、左舌回的fALFF升高（1.11±0.09对0.99±0.08），差异有统计学意义（t=?5.64、4.61，均P<0.05）。首发抑郁症患者右前扣带回ALFF值与患者HAMD-17评分呈负相关（r=?0.640，P=0.006），而右旁扣带回ALFF值、右前扣带回及左舌回fALFF与患者HAMD-17评分均无相关性。 结论 静息状态下首发抑郁症患者右前扣带回及左舌回的ALFF值和fALFF可能发生变化，这些脑区的自发性脑神经活动异常可能与HAMD-17评分有一定的相关性。

Preliminary research on amplitude of low frequency fluctuation of resting state functional magnetic resonance imaging in first-episode major depressive disorder patients

Objective To investigate the alteration of baseline brain activity levels in first-episode depressive disorder patients by the amplitude of low frequency fluctuation (ALFF) and fractional amplitude of low frequency fluctuation (fALFF) based on the resting state functional magnetic resonance imaging (rs-fMRI). The correlations between the scores of HAMD-17 and the abnormal brain regions of ALFF and fALFF were analyzed. Methods Seventeen first-episode depressive patients (depression group: 5 males and 12 females, aged 19?54 years old) and 17 normal volunteers (control group: 8 males and 9 females, aged 20?58 years old) awere enrolled. Demographic data and HAMD-17 scores of the two groups were collected and analyzed by retrospective analysis, and rs-fMRI scanning was performed on the two groups. Based on the MATLAB R2017a platform, ALFF and fALFF methods were used to analyze the resting state scanning data. The ALFF and fALFF values of the two groups were compared by using DPABI v4.3 statistical software. The brain regions with statistically significant differences between the two groups were extracted by REST1.8 software. SPSS19.0 was used to analyze the demographic data. Two independent samples t-test was used for continuous variables with normal distributions. Pearson correlation analysis was performed between these brain regions and HAMD-17 scores. Results Compared with the control group, the depressive disorder patients of depression group had decreased ALFF in the right anterior cingulate (0.51±0.11 vs. 0.76±0.12) and right anterior cingulate and paracingulate gyrus (0.56±0.08 vs. 0.77±0.16), the difference was statistically significant (t=?7.08, ?4.56, both P<0.05). Compared with the control group, the disorder patients of depressive group showed decreased fALFF in the right anterior cingulate (0.96±0.06 vs. 1.04±0.05), and increased fALFF in left lingual gyrus (1.11±0.09 vs. 0.99±0.08), the difference was statistically significant (t=?5.64, 4.61, both P<0.05). A negative correlation among ALFF values was found in the right anterior cingulate cortex and HAMD-17 score in first-episode depression patients (r=?0.640, P=0.006), whereas no correlation was found among ALFF values in the right anterior cingulate cortex, fALFF in the right anterior cingulate and left lingual gyrus, and HAMD-17 scores. Conclusions The values of ALFF and fALFF in the right anterior cingulate gyrus and left lingual gyrus may change in first-episode depression patients under resting state. The spontaneous abnormal brain nerve activity in these brain regions may be related to HAMD-17 scores.