Ki-67预测肺腺癌患者预后价值的Meta分析

目的:通过Meta分析评估Ki-67能否作为判断肺腺癌患者预后的指标。方法:系统检索PubMed、EMBase和Cochrane数据库获得相关文章,提取文章信息并完成文章质量评价后,利用R 3.6.1软件评估Ki-67高表达对肺腺癌患者及其不同亚组预后的影响。结果:共纳入27篇文章的28项研究。结果显示,在肺腺癌患者中,Ki-67表达与总体生存期(overall survival,OS,HR:1.15,P=0.000 1)和无病生存期(disease-free survival,DFS,HR:2.12,P=0.000 3)呈负相关。种族方面,目前仅在亚洲患者中提示Ki-67高表达患者的预后较差;而在不同分期、不同临界值组均提示Ki-67高表达者预后不良。Ki-67临界值定义在50%是目前的最佳临界值。结论:Ki-67高表达在预测肺腺癌预后方面具有临床意义,未来需要进行更多高质量前瞻性研究来验证完善这一发现。

Prognostic value of Ki-67 in patients with lung adenocarcinoma:A Meta-analysis

Objective:To evaluate whether Ki-67 could be used as a biomarker for judging the prognosis of patients with lung adenocarcinoma by Meta-analysis.Methods:We systemically searched PubMed,EMBase,and Cochrane databases to obtain related articles.After extracting the article information and completing the article quality evaluation,R 3.6.1 software was used to evaluate the effect of Ki-67 overexpression on the prognosis of patients with adenocarcinoma and its subgroups.Results:A total of 27 artciles with 28 studies were included.The results showed that Ki-67 expression was negatively correlated with overall survival(OS,HR:1.15,P=0.000 1) and disease-free survival(DFS,HR:2.12,P=0.000 3) in patients with adenocarcinoma.In terms of race,among Asian patients,patients with high Ki-67 expression had a worse prognosis.Patients with high Ki-67 expression have a poor prognosis in different stages and cut-offs.The Ki-67 cut-off value defined at 50%was the current best cut-off value.Conclusion:The high expression of Ki-67 has clinical significance in the prognosis of adenocarcinoma,and more high-quality prospective studies will be needed to verify and improve this finding in the future.