| 药物相关性颌骨坏死的研究进展 |
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| 引用本文： | 杨 涛,魏建华,雷德林,杨耀武,杨新杰,王 艳,张春谊,魏 丽.药物相关性颌骨坏死的研究进展[J].现代肿瘤医学,2020,0(6):1039-1042. |
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| 作者姓名： | 杨 涛 魏建华 雷德林 杨耀武 杨新杰 王 艳 张春谊 魏 丽 |
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| 作者单位： | 军事口腔医学国家重点实验室，国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心，第四军医大学口腔医院头颈肿瘤外科，陕西 西安 710032 |
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| 摘 要： | 双磷酸盐（bisphosphonates，BPs）等药物通过抗血管生成，同时抑制骨吸收，进而增强骨质被广泛应用于临床，但此类药常导致颌骨严重并发症，引起广泛关注。本文对药物相关性骨坏死（medication-related osteonecrosis of the jaw ，MRONJ）研究进行总结，为此类疾病的临床治疗提供一定帮助。
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| 关 键 词： | 双磷酸盐 药物相关性 抗肿瘤 颌骨坏死 颌骨感染 |
New research program of medication-related osteonecrosis of the jaw |
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| Yang Tao,Wei Jianhua,Lei Delin,Yang Yaowu,Yang Xinjie,Wang Yan,Zhang Chunyi,Wei Li.New research program of medication-related osteonecrosis of the jaw[J].Journal of Modern Oncology,2020,0(6):1039-1042. |
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| Authors: | Yang Tao Wei Jianhua Lei Delin Yang Yaowu Yang Xinjie Wang Yan Zhang Chunyi Wei Li |
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| Institution: | State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology，Shaanxi Clinical Research Center for Oral Diseases，Department of Head and Neck Tumor Surgery，School of Stomatology,t |
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| Abstract: | The bisphosphonates（BPs）by inhibiting osteoclast activity and resistance to bone resorption to improve the effect of osteoporosis has been confirmed,but has gained wide attention as a severe side effect.In this paper,the studies of drug-related osteonecrosis of the jaw (MRONJ) were summarized,providing some help for the clinical diagnosis and treatment. |
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| Keywords: | bisphosphonates medication-related antineoplasms jaw osteonecrosis infection |
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