| 建立初诊肺癌患者骨转移风险评估模型 |
| |
| 引用本文： | 许玉炫1,冯 伟1,庞海林1,' target='_blank'>2,覃文进1,孙 鑫1,刘理礼1,张贺龙1,' target='_blank'>3. 建立初诊肺癌患者骨转移风险评估模型[J]. 现代肿瘤医学, 2020, 0(20): 3525-3530. DOI: 10.3969/j.issn.1672-4992.2020.20.013 |
| |
| 作者姓名： | 许玉炫1 冯 伟1 庞海林1 ' target='_blank'>2 覃文进1 孙 鑫1 刘理礼1 张贺龙1 ' target='_blank'>3 |
| |
| 作者单位： | 1.空军军医大学第二附属医院肿瘤科，陕西 西安 710038;2.国家卫生计生委艾滋病免疫学重点实验室，中国医科大学第一附属医院检验科，辽宁 沈阳 110001;3.空军军医大学肿瘤研究所，陕西 西安 710038 |
| |
| 摘 要： | 目的:建立一个列线图来预测肺癌患者骨转移的风险。方法:收集2012年1月至2019年12月未经任何治疗(包括手术、放疗和化疗)的肺癌患者的临床资料，包括骨转移情况、性别、年龄、病理类型、血清钙浓度、碱性磷酸酶(alkaline phosphatase,ALP)、癌胚抗原(carcinoembryonic antigen,CEA)、T分期、N分期。分析骨转移的危险因素，通过Logistic回归分析建立列线图。结果:在分析的306例患者中，有137例(44.78%)肺癌患者在初次诊断时已经发生骨转移。其中ALP、CEA、病理类型和N分期是新诊肺癌患者骨转移的危险因素，列线图模型曲线下面积(area under curve,AUC)值为 0.867。结论:当临床上出现初诊 ALP 值高、CEA＞7.285 ng/ml、N分期高、腺癌和小细胞癌的患者时，有必要及时对患者进行相关骨转移检查。
|
| 关 键 词： | 肺癌 骨转移 危险因素 列线图 |
Establishing the risk assessment model of bone metastasis in initial diagnosed lung cancer patients |
| |
| Xu Yuxuan1,Feng Wei1,Pang Hailin1,' target='_blank'>2,Qin Wenjin1,Sun Xin1,Liu Lili1,Zhang Helong1,' target='_blank'>3. Establishing the risk assessment model of bone metastasis in initial diagnosed lung cancer patients[J]. Journal of Modern Oncology, 2020, 0(20): 3525-3530. DOI: 10.3969/j.issn.1672-4992.2020.20.013 |
| |
| Authors: | Xu Yuxuan1 Feng Wei1 Pang Hailin1 ' target='_blank'>2 Qin Wenjin1 Sun Xin1 Liu Lili1 Zhang Helong1 ' target='_blank'>3 |
| |
| Affiliation: | 1.Department of Oncology,the Second Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710038,China;2.Key Laboratory of AIDS Immunology of National Health and Family Planning Commission,Department of Laboratory Medicine,the First Affiliated Hospital,China Medical University,Liaoning Shenyang 110001,China;3.Institute of Cancer,Air Force Medical University,Shaanxi Xi'an 710038,China. |
| |
| Abstract: | Objective:To establish a nomogram for predicting the risk of bone metastasis in patients with initial diagnosed lung cancer.Methods:We collected the clinical data of lung cancer patients who were diagnosed from January 2012 to December 2019 without any treatment(including surgery,radiotherapy and chemotherapy),including bone metastasis,gender,age,pathological type,calcium concentration,ALP,CEA,T stage,N stage,to find out the risk factors of bone metastasis,establishing nomogram by Logistic regression analysis.Results:Among the 306 patients analyzed,137(44.78%) had bone metastases at the time of initial diagnosis of lung cancer.ALP,CEA,pathological type and N stage were found to be the risk factors of bone metastasis.The AUC of the nomogram was 0.867.Conclusion:When the patients with high ALP,CEA>7.285 ng/ml,high N stage,adenocarcinoma and small cell carcinoma appear in clinic,it is necessary to carry out bone metastasis examination in time. |
| |
| Keywords: | lung cancer bone metastasis risk factors nomogram |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
|
