健身消导颗粒治疗儿童功能性消化不良的效果观察

目的 探讨健身消导颗粒对儿童功能性消化不良（FD）的疗效。方法 纳入符合罗马Ⅳ标准的 FD患儿120例，按照随机数字表法分为健身消导颗粒治疗组（观察组）和多潘立酮对照组（对照组），每组60例。观察组：健身消导颗粒+L-谷氨酰胺呱仑酸钠颗粒+正确的饮食指导。健身消导颗粒具体服药方法：＜1岁，每次半包，每日 2次；1～6岁，每次1包，每日2次；>6岁，每次1包，每日3次。在餐间或餐后开水冲服。疗程14 d。对照组：多潘立酮混悬液+L-谷氨酰胺呱仑酸钠颗粒+正确的饮食指导。多潘立酮混悬液具体服药方法：按照 0.3 mg/kg标准给药，3次/d。就餐前30 min予以冲服。疗程14 d。受试者于基线期（治疗前）、治疗2周和停药后随访8周时接受3次访视，评价临床症状积分、胃电节律和疗效。结果 2组患儿治疗前胃动过缓及胃电节律异常发生情况比较差异均无统计学意义（均P＞0.05）。2组治疗后餐前餐后胃动过缓及胃电节律异常率均明显低于治疗前（P＜0.01），而观察组治疗后胃动过缓及胃电节律异常率均明显低于对照组（P＜0.05）。观察组患儿的治疗2周总有效率为95%，停药随访8周有效率为91.7%；对照组总有效率为81.7%，停药随访8周有效率75.0%，2组差异有统计学意义（P＜0.05）。结论 健身消导 颗粒能有效改善胃肠功能，提高FD患儿疗效，提高患儿生活质量，且疗效持续至停药8周后，值得临床进一步推广。

Effects of jianshenxiaodao granule on children with functional dyspepsia

Objective To evaluate the efficacy of jianshenxiaodao granule for children with functional dyspepsia (FD). Methods From December 2016 to November 2018, 120 patients met Rome IV criteria were enrolled and divided into jianshenxiaodao granule group and domperidone group. Clinical symptoms and electrogastrogram were observed before and after treatment in two groups. The clinical efficacy of two groups was compared after two-week treatment and two-week follow-up. Results There were no significant differences in the sex, age, duration of disease, number of basal symptoms including abdominal pain, anorexia, sour regurgitation, belchin, nausea and vomiting between two groups (P＞0.05). In the 2 groups after treatment (before meal and after meal), the gastric motility and the abnormal rate of gastric electrical rhythm were significantly decreased (P＜0.05). The total effective rate was better in observation group than that of control group (P＜0.05). Conclusion The jianshenxiaodao granule can significantly improve the clinical symptoms of children with FD,enhance the gastric motility and improve the clinical efficacy that lasts until 8 weeks after drug withdrawal, which is worthy of further clinical promotion.