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EN2在胶质母细胞瘤中的表达及其预后价值
引用本文:梁若飞,杨彬彬,唐晓平. EN2在胶质母细胞瘤中的表达及其预后价值[J]. 现代肿瘤医学, 2020, 0(16): 2783-2786. DOI: 10.3969/j.issn.1672-4992.2020.16.011
作者姓名:梁若飞  杨彬彬  唐晓平
作者单位:川北医学院附属医院神经外科,四川 南充 637000
基金项目:南充市科学技术和知识产权局资助项目(编号:18SXHZ0347);川北医学院博士科研启动基金项目(编号:CBY18-QD04)
摘    要:目的:探讨EN2在胶质母细胞瘤中的表达及其预后价值。方法:利用Oncomine 数据库及GEPIA数据库分析EN2 在胶质母细胞瘤组织中的表达情况;检索GEPIA数据库,分析EN2 在胶质母细胞瘤组织中的表达与预后的相关性。结果:在胶质母细胞瘤组织中EN2的mRNA表达显著高于正常对照组(P<0.05);EN2的mRNA表达量与胶质母细胞瘤总生存期存在相关性,即低表达EN2的患者预后较好,高表达EN2的患者预后较差(P=0.015)。结论:EN2基因在胶质母细胞瘤组织中呈高表达,其表达水平对预测胶质母细胞瘤患者的预后具有重要意义。

关 键 词:EN2  胶质母细胞瘤  表达  预后

Expression of EN2 and its prognostic significance in glioblastoma
Liang Ruofei,Yang Binbin,Tang Xiaoping. Expression of EN2 and its prognostic significance in glioblastoma[J]. Journal of Modern Oncology, 2020, 0(16): 2783-2786. DOI: 10.3969/j.issn.1672-4992.2020.16.011
Authors:Liang Ruofei  Yang Binbin  Tang Xiaoping
Affiliation:Department of Neurosurgery,Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China.
Abstract:Objective:To investigate the expression and prognostic significance of EN2 in glioblastoma.Methods:The expression of EN2 in glioblastoma tissues was measured in Oncomine database and GEPIA.The correlation between EN2 and the survival time of patients with glioblastoma was analyzed by GEPIA.Results:The mRNA expression of EN2 was significantly increased in glioblastoma tissues than normal tissues(P<0.05).Moreover,increased expression of EN2 was significantly correlated with poor overall prognosis in patients with glioblastoma(P=0.015).Conclusion:EN2 gene shows high expression in glioblastoma tissues,and its expression level has vital significance in predicting the prognosis of glioblastoma.
Keywords:EN2   glioblastoma   expression   prognosis
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