Down-regulation of Na channel expression by A23187 in NlE-115 neuroblastoma cells |
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| Authors: | Jody K Hirsh Fred N Quandt |
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| Institution: | The Multiple Sclerosis Center and Department of Molecular Biophysics and Physiology, Rush University, 1750 West Harrison Street, Chicago, IL 60612, USA |
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| Abstract: | Growth of cultured NlE-115 neuroblastoma cells in 1 μM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal Ca may therefore control excitability by independent regulation of Na and K channel mRNA abundance in neurons. |
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