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An age-dependent novel hyperinnervation of circumvallate papillae by tyrosine hydroxylase-containing nerve fibers in NGF-overexpressing transgenic mice |
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| Authors: | Shigeru Takami Marilyn L. Getchell Kathryn M. Albers Thomas V. Getchell |
| Affiliation: | aDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536-0084, USA;bDivision of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Kentucky College of Medicine, Lexington, KY 40536-0084, USA;cSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536-0084, USA;dDepartment of Pathology, University of Kentucky College of Medicine, Lexington, KY 40536-0084, USA |
| Abstract: | The density of protein gene product 9.5- and tyrosine hydroxylase-immunoreactive nerve fibers innervating circumvallate papillae of the tongue was substantially increased in transgenic mice that overexpressed nerve growth factor (NGF) when compared with age-matched controls. The fiber density was age-dependent. Only transgenic mice contained NGF-immunoreactive basal cells in the vicinity of taste buds, indicating that target-derived NGF induced novel hyperinnervation of the circumvallate papillae. |
| Keywords: | Circumvallate papilla Transgenic mouse Nerve growth factor Protein gene product 9.5 Tyrosine hydroxylase Aging |
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