Brain metastases from transitional cell carcinoma

We report 2 cases of transitional cell carcinoma, each with a single metastasis to the brain. Both patients underwent craniotomy with resection of the metastatic deposit and adjuvant whole brain radiotherapy. One patient died 4 months later of leptomeningeal carcinomatosis, while the other patient survived 1 year with no evidence of intracranial disease at autopsy despite widespread metastatic involvement of other organs.