低剂量丙种球蛋白与复方丹参注射液联合治疗儿童过敏性紫癜疗效评价

目的:观察低剂量丙种球蛋白(丙球)与复方丹参注射液联合治疗儿童过敏性紫癜(HSP)的疗效.方法:将87例HSP患者随机分为3组,对照组给予常规激素治疗,丙球治疗组给予常规剂量丙种球蛋白治疗,联合治疗组则采用低剂量丙球与复方丹参注射液治疗.结果:联合治疗组有效率为92.9%,治疗后4周紫癜性肾炎发生率为7.1%,随访6个月后复发率为10.7%;丙球治疗组有效率为89.7%,治疗后4周紫癜性肾炎发生率为10.3%,随访6个月后复发率为13.8%;对照组有效率为73.3%,紫癜性肾炎发生率及复发率均为33.3%.经统计学处理,两治疗组疗效及预防复发均优于对照组(P＜0.05),但两治疗组间疗效及复发并无显著性差异.结论:低剂量丙球与复方丹参注射液联合治疗HSP不但能缩短疗程,而且能减少紫癜性肾炎的发生率,预防复发.

Therapeutic alliance effect of low dose gamma globulin and compound danshen injection on henoch-schonlein purpura in children

Objective: To discuss the clinical curative effect of low dose gamma globlinand compound Danshen injection on henoch-schonlein purpura in children.Methods: 87 cases were randomly divided into 3 groups.Routine treatment was given to control group,while normal dose treatment group was added to normal dose gamma globulin and union treatment group was treated by low dose gamma globulin and Compound Danshen injection.Results: The total effective rate in union treatment group was 92.8%,the rate of purpuric nephritis is 7.1% after 4 weeks treatment,and the Recurring rate is 10.7% after 6 months.The effective rate of normal dose gamma globulin group was 89.7%,the rate of purpura nephritis is 10.3% after 4 weeks treatment,and the Recurring rate is 13.8% after 6 months.There was no difference between two of them.But they were all much higher than that in control group(P<0.05).Conclusions: Therapeutic alliance of low dose Gamma globulin and Compound Danshen injection can raise the curative effect on HSP in children.