Angiogenesis and anti-angiogenesis in hepatocellular carcinoma |
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Authors: | Ribatti Domenico Vacca Angelo Nico Beatrice Sansonno Domenico Dammacco Franco |
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Affiliation: | Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy. ribatti@anatomia.uniba.it |
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Abstract: | Experimental and clinical data indicate that in human hepatocellular carcinoma (HCC) tumor progression is associated with angiogenesis and that an increase in microvascular density is associated with a poor prognosis. This review summarizes the literature concerning the relationship between angiogenesis and progression in HCC. It is becoming increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed. |
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Keywords: | Angiogenesis Anti-angiogenesis Hepatocellular carcinoma Tumor progression |
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