| 卵巢癌DNA甲基化的研究进展 |
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| 引用本文： | 于歌综述,王晶审校. 卵巢癌DNA甲基化的研究进展[J]. 实用肿瘤学杂志, 2013, 27(1): 81-84. DOI: 10.3969/j.issn.1002-3070.2013.01.018 |
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| 作者姓名： | 于歌综述 王晶审校 |
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| 作者单位： | 哈尔滨医科大学附属第三医院(哈尔滨 150081) |
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| 摘 要： | 卵巢癌是死亡率最高的妇科恶性肿瘤之一, 其发生、发展及耐药机制与DNA 甲基化关系密切。通过改变启动子CpG岛甲基化状态调控基因表达, 甲基化改变相对稳定并能在血清中检测到, 可以作为微创检查的生物标志。深入研究DNA甲基化作用机制将有助于卵巢癌早期诊断、辅助治疗和预后判断。
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| 收稿时间： | 2011-08-03 |
The research progress of DNA methylation in ovarian cancer |
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| YU Ge,WANG Jing. The research progress of DNA methylation in ovarian cancer[J]. Journal of Practical Oncology, 2013, 27(1): 81-84. DOI: 10.3969/j.issn.1002-3070.2013.01.018 |
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| Authors: | YU Ge WANG Jing |
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| Affiliation: | Department of Gynecology, The Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China |
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| Abstract: | Objective DNA methylation is intimately associated with tumorigenesis, progression and chemoresistance of ovarian cancer, which is the most lethal gynecologic malignancy.It regulates the expression of genes through altered DNA methylation at CpG islands of promoter.Aberration of methylation is relatively stable.Detection of methylation biomarkers in the serum has potential as a minimally invasive detection tool.A greater understanding of the mechanism of DNA methylation in ovarian cancer will be useful for improving early diagnostic, therapeutic responsiveness and evaluation of prognosis. |
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