Oral immunization with a combination of Plasmodium yoelii merozoite surface proteins 1 and 4/5 enhances protection against lethal malaria challenge |
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Authors: | Wang Lina Goschnick Matthew W Coppel Ross L |
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Affiliation: | Department of Microbiology, Monash University, Clayton, Victoria, Australia. |
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Abstract: | Oral immunization of mice with Escherichia coli-expressed Plasmodium yoelii merozoite surface protein 4/5 or the C-terminal 19-kDa fragment of merozoite surface protein 1 induced systemic antibody responses and protected mice against lethal malaria infection. A combination of these two proteins administered orally conferred improved protection compared to that conferred by either protein administered alone. |
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