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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency |
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| Authors: | Kezic Sanja O'Regan Gráinne M Lutter René Jakasa Ivone Koster Ellen S Saunders Sean Caspers Peter Kemperman Patrick M J H Puppels Gerwin J Sandilands Aileen Chen Huijia Campbell Linda E Kroboth Karin Watson Rosemarie Fallon Padraic G McLean W H Irwin Irvine Alan D |
| Affiliation: | a Coronel Institute of Occupational Health, Academic Medical Center, Amsterdam, The Netherlands b National Children's Research Centre, Our Lady’s Children’s Hospital, Dublin, Ireland c Department of Paediatric Dermatology, Our Lady’s Children’s Hospital, Dublin, Ireland d Departments of Experimental Immunology and Respiratory Medicine, Academic Medical Centre and University of Amsterdam, Amsterdam, The Netherlands e Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia f Center for Optical Diagnostics and Therapy, Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands g River Diagnostics BV, Rotterdam, The Netherlands h Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands i Epithelial Genetics Group, Medical Sciences Institute, University of Dundee, Dundee, United Kingdom j Department of Medicine, Trinity College, Dublin, Ireland |
| Abstract: | |
| Keywords: | Atopic dermatitis confocal Raman spectroscopy eczema filaggrin natural moisturizing factor pH transepidermal water loss IL-1 IL-18 skin barrier FLG gene mutations Flgft/Flgft (FlgdelAPfal) mice |
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