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Brain metastases from epithelial ovarian carcinoma: evaluation of prognosis and managements - a Taiwanese Gynecologic Oncology Group (TGOG) study
Authors:Chiang Ying-Cheng  Qiu Jian-Tai  Chang Chih-Long  Wang Peng-Hui  Ho Chih-Ming  Lin Wu-Chou  Huang Yu-Fang  Lin Hao  Lu Chien-Hsing  Chou Cheng-Yang
Affiliation:
  • a Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
  • b Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital (CGMH-Linko), Taoyuan, Taiwan
  • c Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
  • d Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
  • e Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
  • f Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
  • g Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan
  • h Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
  • i Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
    		•
    Abstract:

    Objective

    To evaluate the characteristics and outcome of patients with brain metastases from epithelial ovarian carcinoma.

    Methods

    The clinical and pathologic characteristics, treatment and outcome of patients with brain metastases from epithelial ovarian carcinoma were analyzed from eight medical centers in Taiwan under the TGOG (Taiwanese Gynecologic Oncology Group).

    Results

    A total of 64 patients were recruited in this study. The incidence of brain metastases from epithelial ovarian carcinoma seemed to be increasing in recent years. The median survival from the diagnosis of brain metastases was 8 months (range: 0-72). Prior cancer relapse before the diagnosis of brain metastases, number of brain metastases and multimodal treatment were related to the duration of survival.

    Conclusions

    The prognosis for patients with brain metastases from epithelial ovarian carcinoma is generally poor. However, clinicians should keep alert to the neurological complaints of ovarian cancer patients and the patients might benefit from aggressive multimodal treatments.
    Keywords:Ovarian cancer   Brain metastases   Multimodal treatment
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