首页 | 本学科首页   官方微博 | 高级检索  
检索        


Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment
Authors:Yawu Liu  Gabriela SpulberKimmo K Lehtimäki  Mervi Könönen  Ilona HallikainenHeidi Gröhn  Miia Kivipelto  Merja HallikainenRitva Vanninen  Hilkka Soininen
Institution:a Department of Clinical Radiology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio, Finland
b Department of Neurology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio, Finland
c Department of Clinical Neurophysiology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio, Finland
d Department of Neurology, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland
e Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, P.O. Box 1627, FI-70211 Kuopio, Finland
f Aging Research Center, Karolinska Institutet, Stockholm, Sweden
Abstract:We aimed to explore the changes in fractional anisotropy (FA) in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) by analyzing diffusion tensor imaging (DTI) data using the Tract-Based Spatial Statistics (TBSS). DTI data were collected from 17 AD patients, 27 MCI subjects and 19 healthy controls. Voxel-based analysis with TBSS was used to compare FA among the three groups. Additionally, guided by TBSS findings, a region of interest (ROI)-based analysis along the TBSS skeleton was performed on group-level and the accuracy of the method was assessed by the back-projection of ROIs to the native space FA. Neurofiber tracts with decreased FA included: the parahippocampal white matter, cingulum, uncinate fasciculus, inferior and superior longitudinal fasciculus, corpus callosum, fornix, tracts in brain stem, and cerebellar tracts. Quantitative ROI-analysis further demonstrated the significant decrease on FA values in AD patients relative to controls whereas FA values of MCI patients were found in between the controls and AD patients. We conclude that TBSS is a promising method in examining the degeneration of neurofiber tracts in MCI and AD patients.
Keywords:Alzheimer's disease  Diagnostics  Diffusion tensor imaging  Mild cognitive impairment  MRI  Voxel-based method
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号