Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can) |
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| Authors: | Ulmer Hanno Bjørge Tone Concin Hans Lukanova Annekatrin Manjer Jonas Hallmans Göran Borena Wegene Häggström Christel Engeland Anders Almquist Martin Jonsson Håkan Selmer Randi Stattin Pär Tretli Steinar Kleiner Andrea Stocks Tanja Nagel Gabriele |
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| Affiliation: | a Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Austriab Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norwayc Norwegian Institute of Public Health, Oslo/Bergen, Norwayd Agency for Preventive and Social Medicine, Bregenz, Austriae Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germanyf Department of Surgery, Skåne University Hospital Malmö, Malmö, Swedeng Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Swedenh Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Swedeni Department of Surgery, Skåne University Hospital Lund, Lund, Swedenj Department of Radiation Science, Oncology, Umeå University, Umeå, Swedenk Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USAl Institute of Population-based Cancer Research, Cancer Registry of Norway, Oslo, Norwaym Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germanyn Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark |
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| Abstract: | BackgroundLittle is known about the association between metabolic risk factors and cervical cancer carcinogenesis.Material and methodsDuring mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements.ResultsBMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70 years 1.34; 1.00-1.81), triglycerides (50-70 years 1.49, 1.03-2.16 and ≥ 70 years 1.54, 1.09-2.19) and glucose (≥ 70 years 1.87, 1.13-3.11) were associated with increased cervical cancer risk.ConclusionThe presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer. |
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| Keywords: | Metabolic factors Cervical cancer Epidemiology CONOR |
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