糖尿病周围神经病变神经损害特点及相关因素分析

目的 探讨糖尿病周围神经病变（DPN）的神经损害特点及相关危险因素. 方法 根据神经传导速度（NCV）将T2DM患者分为DPN组和无DPN（NDPN）组,分析各组糖尿病病程、BP、FPG、HbA1c、BMI、血脂,以及体感诱发电位等. 结果 年龄、病程是DPN发生的危险因素（OR=1-096、1.121,P＜0.05）.SBP、FPG、TG、TC与DPN呈正相关,但差异无统计学意义（P＞0.05）.HDL-C为DPN的保护因素（OR=2.013,P＜0.05）.粗有髓鞘神经纤维及细有髓鞘神经纤维病变组HDL-C水平下降（P＜0.05）,且下肢细有髓神经纤维是DPN的好发部位. 结论 糖尿病患者增龄、病程长是DPN的危险因素,HDL-C降低与DPN发生发展密切相关.

The characteristic of nerve damage of diabetic peripheral neuropathy and its related factors

Objective To investigate the characteristic of nerve injury and its related factors of diabetic peripheral neuropathy（DPN）. Methods Patients of T2DM were divided into DPN group and NDPN group according to nerve conduction velocity. Diabetic duration, fasting plasma glucose（FPG）, HhA1c, body mass index（BMI）, blood pressure, blood lipids, somatosensory evoked potential of each group were detected and analyzed. ResNls Age and diabetic duration were the risk factors of DNP （OR = 1. 096,1.121, P〉0.05 ） ; Systolic blood pressure （ SNP）, FPG, triglycerides （TG）, total cholesterol （TC） had positive correlations with DNP possibly （P〉 0.05）; High density lipoprotein-cholesterol （HDL-C） was the protective factor of DPN（OR = 2. 013, P〈0.05）. Compared with NDPN group, HDLC level decreased obviously in patients with both thick and thin myelinated nerve fibers damage （P〈0.05）. The predilection sites of DNP were in thin myelinated nerve fibers of lower limbs （P〈0.01）. Conclusion Diabetic duration, age were identified as risk factors of DPN, lower HDL-C was closely related to occurring and developing of DPN.