银芷肛肠熏洗剂对大鼠痔相近模型局部炎症及组织病理学的影响

目的观察银芷肛肠熏洗剂对大鼠痔相近模型局部症状和组织病理学改变的影响。方法采用肛门外周注射冰醋酸法制作大鼠痔相近模型,造模成功后将建模成功的大鼠随机分为银芷肛肠熏洗剂高、中、低剂量组,马应龙金玄痔科熏洗散对照组和正常对照组,连续给药7d,于给药后2、4、7d观察给药后大鼠的一般情况,局部红肿、炎性渗出及溃疡面积,判断药物的抗炎、促溃疡愈合作用,于第8天观察后处死动物,通过病理组织学检查,观察药物对动物模型病理学改变的改善情况。结果给药后银芷肛肠熏洗剂高、中、低剂量组改善局部症状的作用优于正常对照组及金玄痔科熏洗散对照组（P〈0.01/0.05）;银芷肛肠熏洗剂高、中、低剂量组改善痔相近动物模型病理学改变的作用优于正常对照组及金玄痔科熏洗散对照组（P〈0.01/0.05）。结论银芷肛肠熏洗剂能显著改善动物模型的局部症状,具有抗炎、促愈作用;具有改善动物模型病理学改变的作用。

The Local Inflammation and Histopathological Effects of YinZhi Anorectal SmokedLotion Act on Similar Hemorrhoid Model of Rats

Objective To observe the local inflammation and histopathological changing effects of YinZhi anorectal smoked lotion act on similar hemorrhoid model of rats. Methods To make similar hemorrhoid animal model use peripheral injection of acetic acid method. After the animal models are made successfully,the rats were randomly divided to YinZhi anorectal smoked lotion high,medium,low dose group,Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group. Rats were in continuous administration of seven days. After administration of 2,4,7 days observed the rats by general check on local swelling,inflammatory exudate and the ulcer area,estimated the effect of the anti-inflammatory drugs,and promoting ulcer healing,On the8th day the animals were killed after observing. By histopathological examination,do observation of drugs on animal models of pathological changes to improve the situation. Results YinZhi anorectal smoked lotion high,medium and low dose groups after administration,have better effect than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group on the improving the local symptoms（P〈 0.01/0.05）. YinZhi anorectal smoked lotion high, medium and low dose groups after administration,have better effect than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group on improving histopathological changing of similar hemorrhoid model of animals（P〈0.01/0.05）. Conclusion YinZhi anorectal smoked lotion can significantly improve the similar animal model of local symptoms;It has anti-inflammatory and promote ulcer healing;It has a fuction of improving pathological changes of the animal models.