百合地黄汤治疗阴虚型心理亚健康状态人群100例临床研究

目的通过临床随机对照方法研究＂百合地黄汤＂对阴虚型心理亚健康人群干预的效果,探讨中医经方在心理亚健康方面的预防保健作用。方法将阴虚型心理亚健康状态患者按2∶1比例随机分为治疗组和对照组,填写心理亚健康中医证候临床评估表及症状自评量表（SCL-90）;治疗组给予中药免煎颗粒治疗：百合20 g,生地20 g,温水冲服,每日2次,4周为1个疗程;对照组予谷维素20 mg/次,日服3次。4周后比较2组主要症状消除率及SCL-90积分情况,评价疗效结果及不良反应情况。结果 1心理亚健康状态症状发生率方面,治疗组在精神不振、疲乏无力、失眠多梦、抑郁寡欢、焦躁不安及急躁易怒等症状的发生率优于对照组（P〈0.05）;2阴虚症状中,治疗组在失眠多梦、便秘便干、疲劳乏力、烦躁易怒的症状发生率较对照组下降（P〈0.05）;3治疗前后SCL-90评分改变情况：治疗组在躯体化、强迫症状、人际敏感、特别是焦虑、抑郁方面有明显疗效（P〈0.05）。结论百合地黄汤对心理亚健康患者的临床症状有明显的缓解作用,可以缓解抑郁焦虑证患者的早期症状,延缓或阻断抑郁焦虑证发生。

Clinical Study on Baihe Dihumg Decoction in Treating 100 Cases of Yin Type of Psychological Health Groups

Objective With the method of randomized controlled trials,we observed ＂Baihe Dihumg Decoction＂and analyzed its result the intervention of yin-deficiency type of psychological health groups. Methods Determine the diagnostic criterias of Yin type of psychological sub-health. We randomly assigned the qualified and unqualified patients proportionally 2 to 1 into treatment group and comparison group. Patients need to fill Symptom Checklist（SCL-90）. The comparison group took 20 g free fried particles lily,20 g rehmannia glutinosa mixing with warm water twice a day,a month as a treatment. The treatment group took 20 mg oryzanol three times a day,30 min after meals. To observe the symptom elimination rate,change of SCL-90,efficacy and adverse reactions of these two groups. According to SPSS17. 0 database,we used ANOVA to analyze the groups＇ discrepancy,test to compare the average data,chi-square test（χ2） to compare the frequency. Results 1. The frequency of psychological sub-health symptoms,such as lack of energy,fatigue,insomnia,melancholy,anxiety and testiness,P〈0.05,this group was difference. 2. the symptoms of yin-deficiency,such as insomnia,constipation,fatigue and testiness,P〈0.05. the group was diference. 3. The change of SCL-90 before and after treatment：treatment group had a significant effect on improving somatization,enforcement,interpersonal sensitivity,hostility,especially on anxiety,depression and psychotic. Conclusion Baihe Dihumg Decoction can alleviate significantly the clinical symptoms of psychological sub-health condition patients.