ONSET AND RECOVERY OF ROCURONIUM (ORG 9426) AND VECURONIUM UNDER ENFLURANE ANAESTHESIA |
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| Authors: | MAYER M; DOENICKE A; HOFMANN A; PETER K |
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| Institution: | Institute of Anaesthesiology, LMU München, Innenstadtkliniken, Nußbaumstr 20, 8000 Munchen 2, Germany |
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| Abstract: | We have studied the onset, duration of action and recovery indexof twice the ED90 of rocuronium (Org 9426) (0.6 mg kg–1)and of vecuronium (0.08 mg kg–1) in patients during enf/uraneanaesthesia. Rocuronium had a significantly shorter mean onsettime of 1.8 (SD 0.4) min, compared with vecuronium 3.4 (0.8)min. Clinical duration (time for the first twitch in the train-of-fourto recover to 25% of control) was similar for both drugs (29(10) min vs 31 (12) min). Spontaneous recovery times (TOF ratio70%) did not differ significantly between rocuronium (47 (10)min) and vecuronium (44 (11) min). (Br. J. Anaesth. 1992;69:511–512) |
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