| Abstract: | Previous studies have found an association between elevated second trimester maternal serum α-fetoprotein (MS-AFP), in the absence of fetal anomalies, and adverse pregnancy outcome. We studied the association between elevated second trimester maternal serum β-HCG, now also routinely measured by prenatal screening programs, and adverse pregnancy outcome by reviewing retrospectively the pregnancy outcomes among women with markedly elevated midtrimester β-HCG in our prenatal screening program. Seven (0.23%) of 3,000 consecutively screened women had a serum β-HCG above 5 MOM. Four (57%) of these 7 women had an adverse pregnancy outcome including severe preeclampsia (n = 2), abruptio placentae (n = 1), or preterm labor (n = 1). A concurrently elevated MS-AFP was found in only one of these 4 patients. Elevated midtrimester maternal serum β-HCG may be an independent risk factor for subsequent adverse pregnancy outcomes. |
