星点设计-效应面法优化黄肝微丸的制备工艺

目的:采用挤出滚圆法制备黄肝微丸,筛选最佳处方工艺.方法:用挤出滚圆造粒机制备黄肝微丸;以微丸的粉体学性质及得率为指标,在单因素试验基础上,通过星点设计-效应面法优化制备工艺.结果:制备黄肝微丸的最佳工艺为:挤出速度33 Hz,滚圆速度29 Hz,滚圆时间为12 min,所得微丸的圆整度好、大小均匀、收率高.验证实验证...

Optimizing Preparation of Huanggan Pellets by a Central Composite Design-response Surface Method

Objective: To prepare Huanggan pellets by an extrusion spherification method, and to obtain the optimal formulation technology. Method: Based on powder properties and yield, Huanggan pellets formation was optimized by a single factor test combined with central composite design-response surface method. Results: The optimum conditions for the preparation of Huanggan pellets were as follows: the speed of extrusion was 33 Hz, the speed of spheronization was 29 Hz and the time of spheronization was 12 min. The pellets were obtained with good roundness, uniform size and high yield. Validation experiments showed the optimal formulation process with good reproducibility. Conclusion: The central composite design-response surface method can be used to optimize Huanggan pellets with good prediction. The established preparation process is simple and practical.