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| 妊高征患者血一氧化氮、内皮素和肿瘤坏死因子检测的临床意义 | |
| 引用本文： | 王玉平,施绍红,杨静秀,何浩明,王丽莎. 妊高征患者血一氧化氮、内皮素和肿瘤坏死因子检测的临床意义[J]. 淮海医药, 2003, 21(6): 431-432 |
| 作者姓名： | 王玉平 施绍红 杨静秀 何浩明 王丽莎 |
| 作者单位： | 1. 江苏省连云港市东方医院,妇产科,222042 2. 江苏省连云港市第一人民医院,妇产科,222002 3. 江苏省连云港市第一人民医院,临床免疫研究室,222002 |
| 基金项目： | 江苏省连云港市卫生局科研资助课题 2 0 0 2 31 |
| 摘 要： | 目的 探讨一氧化氮 (NO)、内皮素 (ET)和肿瘤坏死因子 (TNF)含量在妊高征中含量的变化。方法 采用放射免疫分析法检测了 38例妊高征患者血清中NO、ET和TNF含量并与 35名正常孕妇作比较。结果 妊高征患者血中NO水平降低 (P <0 .0 1) ,ET、TNF水平则显著地升高 (P <0 .0 1) ,且与病情的轻重密切相关。结论 妊高征患者血管内皮细胞存在内分泌功能紊乱 ,ET合成增加 ,NO释放减少 ,TNF分泌过多 ,三者反馈调控失衡在妊高征的发病中具有重要的临床价值 |
| 关 键 词： | 妊娠高血压综合征 内皮素 一氧化氮 肿瘤坏死因子 |
| 文章编号： | 1008-7044(2003)06-0431-02 |
| 修稿时间： | 2003-01-02 |
The clinical significance of detection of nitric oxide(NO),endothelin(ET),tumor necrosis factor(TNF) in patients with pregnancy induced hypertension |
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| WANG Yu ping,SHI Shao hong,YANG Jing xiu,et al.. The clinical significance of detection of nitric oxide(NO),endothelin(ET),tumor necrosis factor(TNF) in patients with pregnancy induced hypertension[J]. Journal of Huaihai Medicine, 2003, 21(6): 431-432 | |
| Authors: | WANG Yu ping SHI Shao hong YANG Jing xiu et al. |
| Abstract: | Objective To study the changes of plasma NO,ET,TNF in the course of pregnancy induced hypertension(PIH).Methods The concentration of plasma NO,ET,TNF were detected by radioimmunoassay in 38 patients with PIH and 35 normal pregnancy women.Results The plasma NO level decreaeed markedly( P <0.01) and plasma ET,TNF levels in patients with PIH were significantly higher than those in normal pregnancy women ( P <0.01).Conclusion The functional changes of vessel endothelial cells exited in patients with PIH.And the inblance of endothelial relaxing and contracting factors might play an important role clinically. |
| Keywords: | Pregnancy induced hypertension syndrome Endothelin Nitric oxide Tumor necrosis factor |
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