MTA-2蛋白在喉鳞癌中的表达及其临床意义

目的：研究转移相关蛋白2（metastasis—associated protein2，MTA-2）在喉鳞癌中的表达及其临床意义。方法：应用免疫组化检测了90例喉癌标本（其中40例为具有配对的淋巴结转移标本）中MTA-2的表达及其与患者临床病理因素之间的关系。另选30例新鲜喉鳞癌及癌旁正常喉组织用于MTA-2的mRNA和蛋白检测。结果：正常喉组织相比，MTA-2的mRNA和蛋白在喉鳞癌组织中表达显著增高，且MTA-2的阳性表达与喉鳞癌的低分化、高TNM分期及淋巴结转移密切相关（P〈0．05）。结论：MTA-2的阳性表达与喉鳞癌患者的不良预后显著相关，并可能是喉鳞癌新的标志物及基因治疗靶点。

Expression and clinical significance of MTA-2 protein in laryngeal squamous cell carci-noma

Objective： To explore the expression of MTA - 2 （ metastasis - associated protein 2 ） in laryngeal squa-mous cell carcinoma （LSCC） and its clinical significance. Methods： The expression of MTA -2 and its correlation with clinicopathological factors was examined in 90 cases of LSCC specimens by immunohisfochemistry （ including 40 cases with paired lymph node metastases lesions）. The m~NA and protein expression of MTA -2 were also detected in 30 cases of paired LSCC tissues and normal laryngeal tissues. Results ： Compared with normal laryngeal tissues, the mRNA and protein expression of MTA - 2 were increased in LSCC tissues, and the positive expression of MTA - 2 was closely associated with poor differentiation, higher TNM stage and lymph node metastasis （ P 〈 0.05 ）. Conclu-sion： The positive expression of MTA -2 was associated with poor prognosis of patients with LSCC, and MTA-2 may be a new bionmrker and target of gene therapy.