穿心草防治鼻咽癌放射性口腔黏膜反应的临床研究

目的：观察穿心草对鼻咽癌患者放射性口腔粘膜炎的防治效果。方法：将140例鼻咽癌病人随机分为实验组（放疗＋穿心草煎水含服）和对照组（放疗＋复方硼砂含漱液含漱），观察两组患者出现口腔黏膜反应的时间及反应程度，放疗结束时不同病灶残留的情况。结果：实验组及对照组出现放射性口腔黏膜炎的时问分别为（13．1±2．03）天及（10．5±1．69）天，两组比较有显著性差异（P〈0．05）；放疗开始至第2周末两组发生放射性口腔黏膜炎的分级比较无统计学差异（P〉0．05）；放疗第3、4、5、6、7周末，两组比较有显著性差异（P〈0．01）；实验组及对照组平均放疗时间分别为（52．43±3．18）天及（61．1±2．03）天，（P〈0．05）；实验组的损伤程度明显低于对照组，出现黏膜反应的时间要晚。放疗结束时两组患者鼻咽部及颈部病灶残留情况比较无差异（P〉0．05）。结论：穿心草煎水含服可以延缓口腔黏膜反应发生的时间，改善患者临床症状，提高生活质量，防治鼻咽癌引起的放射性口腔黏膜炎安全有效，值得临床推广应用。

Clinical research of Chuanxincao in the prevention and treatment of radiation-induced oral mucosa reaction in patients with nasopharyngeal cancer

Objective： To study the prevention and treatment effect of radiation - induced oral mucosa reaction in patients with nasopharyngeal carcinoma. Methods：All 140 patients with nasopharyngeal carcinoma were randomly di-vided into two groups：experlmental group （combining radiotherapy with Chuanxincao） and control group （combining radiotherapy with sucking solution dobelli）, the starting time of oral mucosa reaction, reaction degree and residual le-sion after radiotherapy were observed. Results ：The starting time of oral mucosa reaction were （ 13.1 ± 2.03 ） days in patients of the experimental group, （ 10.5 ± 1.69） days in patients of control group, （ P 〈 0.05 ）. The grade of mueosa injury wasnt significantly different in experimental group comparing with the control group from the starting of radio-therapy to the 2 weekend（P 〉0. 05） ;whileit was significantly different from 3 weekend to the 7 weekend （ P 〈 0. O1 ） ; The mean radiation time were （52.43 ± 3.18 ）days in patients of the experimental group while （61.1 ± 2.03 ）days in pa-tients of the control group, （ P 〈 0.05 ）. The experimental group g extent of damage was lower than the control group obviously, the starting time of oral mucosa reaction in experimental group was significantly later than control group. The residual lesion wasnt significantly different in experimental group comparing with control group after radiotherapy （ P 〉 0.05 ）. Conclusion： Chuanxineao can delay the starting time of oral mucosa reaction, improve the clinical symp-toms and life quality. It is effective and safe in prevention and treatment of radiation - induced oral mucosa reaction in patients with nasopharyngeal carcinoma.