Ⅲ型前列腺炎前列腺液中IFN-γ、IL-10、IL-4水平变化与临床症状的相关性

目的探讨Ⅲ型前列腺炎前列腺按摩液中细胞因子IFN-γ、IL-10、Il-4水平变化对临床症状的影响。方法按照美国国立卫生院（NIH）分类方法诊断Ⅲ型前列腺炎共76例。ⅢA型前列腺炎47例，ⅢB型前列腺炎29例。采用美国国立卫生研究院的慢性前列腺炎症状评分表（NIH—CPSI），评估疼痛症状评分、排尿症状评分；采用双抗体夹心酶联免疫法（ELISA）检测前列腺液（EPS）中IFN-γ、IL-10、IL-4水平，分析各细胞因子变化和症状评分的相关性。结果ⅢA、ⅢB型前列腺炎两组疼痛症状和排尿症状评分比较无显著性差异（P〉0．05）；IFN-γ、IL-10、IL-4均和疼痛症状评分呈正相关（P〈0．05），其中IL-10起主要相关；IFN-γ、IL-10、IL-4均和排尿症状评分无相关（P〉0．05）。结论Ⅲ型前列腺炎EPS中IFN-γ、IL-10、IL-4水平和疼痛症状有关，其中IL-10可能起主要作用；但IFN-γ、IL-10、IL-4和排尿症状无相关。

The correlations between IFN-γ,IL-10 and IL-4 levels in expressed prostatic secretions of type Ⅲ prostatitis and clinical symptoms

Objective To discuss IFN-γ, IL-10, IL-4 levels in expressed prostatic secretions（EPS） of type Ⅲ prostatitis and their influence on the symptoms. Methods 76 cases were classified, with type/group Ⅲ A （47 cases）, type/group Ⅲ B （29 cases） according to NIH classification system. NIH pain symptom index and NIH urination symptom index were compared between the two groups; IFN-γ, IL-4 and IL-10 in EPS were detected by double antibody sandwich enzyme-linked immunosorbent assay （ELISA）. Results No significant difference of NIH pain symptom index and NIH urination symptom index was detected between the two groups（P 〉 0.05）. IFN-γ, IL-10 and IL-4 had positive correlation with NIH pain symptom index （P〈0.05）, and IL-10 played the key role. All cytokines had no correlation with NIH urination symptom index （P〉0. 05）. Conclusion IFN-γ, IL-10 and IL-4 in EPS have correlations with pain symptom of type Ⅲ prostatitis, and IL-10 probably plays the key role; while IFN- γ, IL-10 and IL-4 in EPS have no correlations with urination symptom.