新生儿持续肺动脉高压治疗进展

新生儿持续肺动脉高压(PPHN)是由于生后胎儿型循环过渡到成人型循环发生障碍所导致的危重急症,病死率高,治疗棘手,是临床亟待解决的课题。近年来,国内外关于PPHN治疗的研究取得一定的突破,包括一氧化氮吸入疗法、磷酸二酯酶抑制剂、依前列醇及其类似物、内皮素受体拮抗剂及抗氧化剂的应用,现将新近的治疗进展进行综述。

Advances in Management of Persistent Pulmonary Hypertension of the Newborn

Persistent pulmonary hypertension of the newborn(PPHN)is a life-threatening neonatal pathology resulting from poor hemodynamic and respiratory transition to extrauterine life.Because of the significant morbidity and mortality associated with PPHN,there is an urgent need to explore possible therapies for PPHN.Here is to focus mainly on the recent advances in the management of PPHN,including inhaled nitric oxide,prostacyclin and its analogs,phosphodiesterase inhibitor and endothelin receptor blockers,and scav...