| 甘露聚糖肽注射液对进展期胃癌化疗免疫抑制的临床研究 |
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| 引用本文： | 王刚,胡冰,季楚舒,胡长路,江丰收,何义富,王勇,孙玉蓓.甘露聚糖肽注射液对进展期胃癌化疗免疫抑制的临床研究[J].中国医药导报,2011,8(27):67-69. |
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| 作者姓名： | 王刚 胡冰 季楚舒 胡长路 江丰收 何义富 王勇 孙玉蓓 |
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| 作者单位： | 安徽医科大学附属安徽省立医院肿瘤内科,安徽合肥,230000 |
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| 摘 要： | 目的：评价甘露聚糖肽改善进展期胃癌免疫抑制的疗效。方法：入组68例晚期胃癌患者分为FOLFOX4方案组（对照组30例）与甘露聚糖肽联合FOLFOX4方案组（治疗组38例）,于化疗前后检测两组CD3＋CD8＋T细胞亚群、CD3＋CD4＋T细胞亚群、NK细胞和CD4＋CD25＋＋调节性T细胞（CD4＋CD25＋＋Treg）,并于化疗2个周期后评估化疗疗效。结果：治疗组完全缓解率优于对照组（13.15%vs 0%,χ2=4.261,P=0.048）,其他近期疗效指标差异无统计学意义。治疗组CD4＋CD25＋＋Treg治疗前后下降明显（P=0.008）,且治疗后显著低于对照组（P=0.013）,治疗组治疗后CD3＋CD4＋T细胞、NK细胞水平则明显高于对照组治疗后（P=0.43、0.036）。同时治疗组的生活质量评分亦高于对照组,差异有统计学意义（P〈0.05）。结论：晚期胃癌患者化疗中,加用甘露聚糖肽注射液虽能提高化疗完全缓解率,但未见提高疾病控制的近期疗效,但可以显著改善患者的免疫抑制状态。
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| 关 键 词： | 晚期胃癌 甘露聚糖肽 化疗 免疫抑制 |
The clinical research of immunosuppression of Mannatide Injection in advanced gastric carcinoma |
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| WANG Gang,HU Bing,JI Chushu,HU Changlu,JIANG Fengshou,HE Yifu,WANG Yong,SUN Yubei.The clinical research of immunosuppression of Mannatide Injection in advanced gastric carcinoma[J].China Medical Herald,2011,8(27):67-69. |
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| Authors: | WANG Gang HU Bing JI Chushu HU Changlu JIANG Fengshou HE Yifu WANG Yong SUN Yubei |
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| Institution: | WANG Gang,HU Bing,JI Chushu,HU Changlu,JIANG Fengshou,HE Yifu,WANG Yong,SUN Yubei Department of Medical Oncology,Affiliated Anhui Provincial Hospital of Anhui Medical University,Anhui Province,Hefei 23000,China |
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| Abstract: | Objective: To evaluate the efficacy of immunosuppression of Mannatide in the treatment of advanced gastric carcinoma.Methods: 68 pathological specimens of advanced gastric cancer patients were enrolled in two groups randomly.30 patients in control group were given FOLFOX4 chemotherapy.While 38 cases in treatment group were given Mannatide Injection on basis of control group.CD3+CD8+T cell,CD3+CD4+T cell,NK cell and CD4+CD25++Treg in peripheral blood were determined by flow cytometer before and after treatme... |
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| Keywords: | Advanced gastric carcinoma Mannatide Chemotherapy Immunosuppression |
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