| DNA甲基化与宫颈癌的研究进展 |
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| 引用本文： | 巫剑红. DNA甲基化与宫颈癌的研究进展[J]. 医学综述, 2011, 17(20): 3081-3084 |
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| 作者姓名： | 巫剑红 |
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| 作者单位： | 首都医科大学附属北京妇产医院妇科微创中心,北京,100026 |
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| 基金项目： | 北京市教育委员会科技计划面上项目 |
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| 摘 要： | DNA甲基化是最早发现的人类细胞表观遗传学修饰,是继基因突变和基因缺失之外,致抑癌基因失活的第3种机制。现已证实,DNA甲基化是癌变过程的早期事件,存在于多种肿瘤中。近年来研究表明,DNA甲基化与宫颈癌的发生、发展密切相关,并可作为宫颈癌早期诊断的分子标志物。现重点阐述DNA甲基化与宫颈癌的关系及DNA甲基化在宫颈癌诊断中的临床应用前景。
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| 关 键 词： | DNA甲基化 宫颈癌 临床应用 全基因组筛查 |
Research Progress of DNA Methylation and Cervical Cancer |
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| WU Jian-hong. Research Progress of DNA Methylation and Cervical Cancer[J]. Medical Recapitulate, 2011, 17(20): 3081-3084 |
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| Authors: | WU Jian-hong |
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| Affiliation: | WU Jian-hong,DAI Yin-mei.(Department of Minimal Invasive Gynecology Center,Beijing Obstetrics and Gynecology Hospital of Capital Medical University,Beijing 100026,China) |
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| Abstract: | DNA methylation is the first discovered epigenetic modification in human cells and is identified as the third mechanism for inactivating tumor suppressor genes except gene mutation and gene deletion.It has been proved that DNA methylation is an early event in carcinogenesis and is often present in a variety of cancers.In recent years,studies have shown that DNA methylation is associated with the genesis and development of cervical cancer and can serve as a biomarker for the early diagnosis of cervical cance... |
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| Keywords: | DNA methylation Cervical cancer Clinical application Genome-wide screening |
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