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BMI对血压、血糖、糖化血红蛋白及C肽的影响
引用本文:张惠新,姜博仁,李影,李艳香,夏芳珍.BMI对血压、血糖、糖化血红蛋白及C肽的影响[J].中国医药导报,2011,8(28):48-49.
作者姓名:张惠新  姜博仁  李影  李艳香  夏芳珍
作者单位:上海交通大学医学院附属第九人民医院内分泌代谢研究室,上海,200011
摘    要:目的:探讨年龄32~56岁的健康者体质指数(body mass index,BMI)增高对血压、血糖、糖化血红蛋白及C肽的影响。方法:79名健康者按BMI分为标准组(18.5≤BMI〈24,n=44)、超重组(24≤BMI〈28,n=27)及肥胖组(BMI≥28,n=8)三组,比较三组之间血压、血糖、糖化血红蛋白及C肽的变化。结果:随着BMI的增高,收缩压(SBP)(115.8±15.24)mm Hg vs(121.1±18.38)mm Hg vs(133.4±18.36)mm Hg](1 mm Hg=0.133 kPa)、餐后2 h血糖(PBG)(5.76±0.73)mmol/L vs(5.86±0.76)mmol/L vs(6.61±1.85)mmol/L],及糖化血红蛋白(HbA1C)(5.20±0.29)%vs(5.29±0.28)%vs(5.64±0.53)%]显著增高,差异有统计学意义(P=0.033,P=0.048,P=0.004);而舒张压(DBP)(72.57±11.14)mm Hg vs(75.81±10.04)mm Hg vs(80.71±11.31)mm Hg]、空腹血糖(FBG)(5.73±0.52)mmol/L vs(5.48±0.54)mmol/L vs(5.85±0.61)mmol/L]、空腹C肽(1.37±0.81)pmol/L vs(1.26±0.43)pmol/L vs(1.98±0.75)pmol/L]及餐后2 h C肽(2.70±1.14)pmol/Lvs(2.99±1.49)pmol/L vs(3.25±1.53)pmol/L]也有增高趋势,但差异无统计学意义(P=0.137,P=0.107,P=0.110,P=0.530)。结论:肥胖使血压、血糖水平增加,从而增加高血压以及糖尿病的患病风险。

关 键 词:体质指数  血糖  血压  糖化血红蛋白  C肽

Influence of BMI on blood pressure, blood glucose, glycosylated hemoglobin and C-peptide
ZHANG Huixin,JIANG Boren,LI Ying,LI Yanxiang,XIA Fangzhen.Influence of BMI on blood pressure, blood glucose, glycosylated hemoglobin and C-peptide[J].China Medical Herald,2011,8(28):48-49.
Authors:ZHANG Huixin  JIANG Boren  LI Ying  LI Yanxiang  XIA Fangzhen
Institution:Department of Endocrine and Metabolize,the NO.9 People′s Hospital Affiliated to Medicine School of Shanghai Jiaotong University,Shanghai 200011,China
Abstract:Objective: To investigate the influence of body mass index(BMI) increasing on levels of blood pressure,blood glucose,glycosylated hemoglobin and C-peptide in the healthy people aged from 32 to 56.Methods: 79 healthy subjects were divided by BMI to three groups,standard group(18.5≤BMI24,n=44),overweight group(24≤BMI28,n=27) and obese group(BMI≥28,n=8),the levels of blood pressure,blood glucose,glycated hemoglobin and C-peptide among the three groups were compared.Results: With the increasing of BMI,the levels of systolic blood pressure(SBP) (115.8±15.24)mm Hg vs(121.1±18.38)mm Hg vs(133.4±18.36)mm Hg](1 mm Hg=0.133 kPa),2-hour postprandial blood glucose(PBG) (5.76±0.73)mmol/L vs(5.86±0.76)mmol/L vs(6.61±1.85)mmol/L] and glycated hemoglobin(HbA1C) (5.20±0.29)% vs(5.29±0.28)% vs(5.64±0.53)%] were significantly higher with statistically significant(P=0.033,P=0.048,P=0.004);and levels of diastolic blood pressure(DBP) (72.57±11.14)mm Hg vs(75.81±10.04)mm Hg vs(80.71±11.31)mm Hg],fasting glucose(FBG) (5.73±0.52)mmol/L vs(5.48±0.54)mmol/L vs(5.85±0.61)mmol/L],fasting C-peptide (1.37±0.81)pmol/L vs(1.26±0.43)pmol/L vs(1.98±0.75)pmol/L] and postprandial 2 h C peptide (2.70±1.14)pmol/L vs(2.99±1.49)pmol/L vs(3.25±1.53)pmol/L] also tended to increase,but the difference was not significant(P=0.137,P=0.107,P=0.110,P=0.530).Conclusion: Obesity makes levels of blood pressure,blood glucose increase,thereby increasing the risk to high blood pressure,heart disease,cerebrovascular disease and diabetes.
Keywords:BMI  Blood glucose  Blood pressure  Glycated hemoglobin  C-peptide    
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