代谢综合征与脂蛋白脂酶的关系研究进展

代谢综合征是一组复杂的代谢紊乱症候群,包括肥胖、高血糖、高血压、血脂紊乱等。脂蛋白脂酶(LPL)是脂代谢关键酶之一,主要催化乳糜微粒和极低密度脂蛋白中的三酰甘油水解。研究显示LPL缺乏和基因突变会导致脂肪代谢障碍,不同的基因多态性对脂代谢有着不同的影响,HindⅢ和PvuⅡ突变会导致脂代谢紊乱,而S447X多态性可能产生有益的血脂改变。LPL与肥胖、胰岛素抵抗和2型糖尿病等代谢综合征的发病有着密切的关系。

Research on Relationship between Lipoprotein Lipase and Metabolic Syndrone

Metabolic syndrome is a complex metabolic disorder syndrome,including obesity,high blood sugar,blood pressure,blood lipid disorders.Lipoprotein lipase(LPL) is one of the key enzymes in lipid metabolism,the main catalyze of chylomicrons and very low-density lipoprotein hydrolysis into triglycerides.Research showed that LPL deficiency and gene mutations cause lipodystrophy.Dfferent gene polymorphisms have a different impact on lipid metabolism,Hind Ⅲ and Pvu Ⅱ mutations cause lipid metabolism,and the S447X polymorphism may have a beneficial lipid changes.LPL is associated with the incidence of metabolic syndrome including obesity,insulin resistance,type 2 diabetes etc.