| 替罗非班对急性心肌梗死患者经皮冠状动脉介入治疗术后抗炎、促炎因子的影响 |
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| 引用本文： | 潘国洲. 替罗非班对急性心肌梗死患者经皮冠状动脉介入治疗术后抗炎、促炎因子的影响[J]. 中国医药导报, 2011, 8(29): 57-58,60 |
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| 作者姓名： | 潘国洲 |
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| 作者单位： | 广西壮族自治区百色市人民医院心内科,广西百色,533000 |
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| 摘 要： | 目的：研究急性心肌梗死（AMI）患者经皮冠状动脉介入治疗（PCI）术后应用替罗非班对抗炎因子和促炎因子的影响。方法：选择2009年10月～2010年12月我院行PCI的急性心肌梗死患者95例,将其分为常规治疗组（n=54）和替罗非班组（n=41）,两组分别测定术前1 h、术后24 h血清IL-6、IL-10、P-选择素和C反应蛋白（CRP）含量。结果：常规治疗组PCI术后仅IL-6降低（t=2.132,P=0.046）,其他指标均未见明显变化。而替罗非班组术后IL-6（t=4.315,P=0）、CRP（t=2.970,P=0.005）和P-选择素（t=3.308,P=0.002）均较治疗前及常规治疗组显著下降;IL-10上升明显,差异有统计学意义（t=2.424,P=0.020）。结论：替罗非班可抑制血小板聚集,降低促炎因子释放,大大降低PCI术后并发症。
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| 关 键 词： | 替罗非班 经皮冠状动脉介入治疗 急性心肌梗死 炎症 |
Impact analysis of Tirofiban to the anti-inflammatory and pro-inflammatory factors in patients with acute myocardial infarction after PCI |
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| PAN Guozhou. Impact analysis of Tirofiban to the anti-inflammatory and pro-inflammatory factors in patients with acute myocardial infarction after PCI[J]. China Medical Herald, 2011, 8(29): 57-58,60 |
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| Authors: | PAN Guozhou |
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| Affiliation: | PAN Guozhou Department of Cardiology,the People's Hospital of Baise City,Guangxi Zhuang Autonomous Region,Baise 533000,China |
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| Abstract: | Objective: To study the effect of Tirofiban to the anti-inflammatory and pro-inflammatory factors in patients with acute myocardial infarction(AMI) after PCI.Methods: 95 patients with AMI treated by percutaneous coronary intervention(PCI) in our hospital from October 2009 to December 2010 were selected and divided randomly into conventional treatment group(n=54) and Tirofiban group(n=41).The level of IL-6,IL-10,P-selectin and CRP of serum were measured.Results: The level of IL-6 in the conventional treatmen... |
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| Keywords: | Tirofiban Percutaneous coronary intervention Acute myocardial infarction Inflammation |
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