| 盐酸氟西汀与西酞普兰治疗阿尔茨海默病所致抑郁症状随机对照研究 |
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| 引用本文： | 刘辉,王京丽,张海林,刘英,吴炬. 盐酸氟西汀与西酞普兰治疗阿尔茨海默病所致抑郁症状随机对照研究[J]. 中国医药导报, 2011, 8(28): 62-63 |
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| 作者姓名： | 刘辉 王京丽 张海林 刘英 吴炬 |
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| 作者单位： | 1. 总参管理保障部北极寺老干局门诊部,北京,100083
2. 卫材(中国)药业有限公司北京办事处,北京,100022 |
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| 摘 要： | 目的：比较盐酸氟西汀与西酞普兰治疗阿尔茨海默病所致抑郁症状的有效性和安全性。方法：将80例受试者随机分为两组,分别给予盐酸氟西汀和西酞普兰治疗,疗程为8周,于治疗前和治疗后2、4、6、8周末分别采用汉密尔顿抑郁量表（HAMD）和副反应量表（TESS）评定两药的疗效及不良反应。结果：在用药2周后,西酞普兰组HAMD得分较治疗前显著下降（P〈0.05）,在治疗4周后盐酸氟西汀组较治疗前显著下降（P〈0.05）,两组在用药8周后,疗效相当（P〉0.05）。两组不良反应均较轻,西酞普兰组的总体不良反应发生率（38.1%）低于盐酸氟西汀组（60.5%）（P〈0.05）。结论：在治疗阿尔茨海默病所致抑郁症方面,西酞普兰起效较快,且较盐酸氟西汀安全性好。两组长期使用疗效相当。西酞普兰适合阿尔茨海默病所致抑郁患者服用。
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| 关 键 词： | 盐酸氟西汀 西酞普兰 阿尔茨海默病 抑郁 |
A randomized controlled study of Fluoxetine and Citalopram on the treatment of depressive symptom due to Alzheimer's disease |
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| LIU Hui,WANG Jinglie,ZHANG Hailing,LIU Ying,WU Ju. A randomized controlled study of Fluoxetine and Citalopram on the treatment of depressive symptom due to Alzheimer's disease[J]. China Medical Herald, 2011, 8(28): 62-63 |
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| Authors: | LIU Hui WANG Jinglie ZHANG Hailing LIU Ying WU Ju |
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| Affiliation: | LIU Hui1,WANG Jinglie,ZHANG Hailing1,LIU Ying1,WU Ju2 1.Beijisi Clinic of the General Staff,Beijing 100083,China,2.Eisai China Inc.,Beijing 100022 |
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| Abstract: | Objective: To compare the efficacy and safety of Fluoxetine and Citalopram in treatment of the depressive symptom due to Alzheimer's Disease.Methods: 80 cases of patients were randomly divided into two groups,the patients of two groups were treated with Fluoxetine and Citalopram respectively;the course was 8 weeks;HAMD and TESS was adopted to assess the clinical effect and adverse reaction.Results: HAMD of Citalopram group decreased significantly after two weeks' treatment(P<0.05),and HAMD of Fluoxetine gro... |
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| Keywords: | Fluoxetine Citalopram Alzheimer's Disease Depressive |
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