| 高频振荡叠加同步间歇指令通气治疗新生儿胎粪吸入综合征 |
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| 引用本文： | 武荣,韩良荣,李娜,郑国方. 高频振荡叠加同步间歇指令通气治疗新生儿胎粪吸入综合征[J]. 中国医药导报, 2011, 8(28): 32-33,36 |
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| 作者姓名： | 武荣 韩良荣 李娜 郑国方 |
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| 作者单位： | 扬州大学医学院附属淮安市妇幼保健院新生儿科,江苏淮安,223002 |
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| 摘 要： | 目的：观察高频振荡通气（HFOV）叠加同步间歇指令通气（SIMV）治疗新生儿胎粪吸入综合征的效果。方法：实施HFOV＋SIMV的叠加模式治疗12例胎粪吸入综合征患儿,采用最小压力策略,通过逐渐增加平均气道压以实现吸入氧体积分数〈0.6时,经皮氧饱和度〉0.9,根据PCO2调整震荡幅度（△P）和频率（f）,最终维持正常血气。治疗过程中监测心率、血压、动脉血气、氧合指数及呼吸机参数。结果：12例患儿在施行HFOV治疗48 h后,氧合指数逐渐下降,在各个时间点比较,差异有统计学意义（F=12.996,P=0.000）;所需的平均呼吸道压力明显下降,各个时间点比较,差异有统计学意义（F=8.712,P=0.000）;所需的FiO2逐渐下降,各个时间点比较,差异有统计学意义（F=29.095,P=0.000）;所需振荡压力幅度逐渐下降,各个时间点比较,差异有统计学意义（F=5.587,P=0.001）;心率、血压在各个时间点比较,差异均无统计学意义（F=1.095,P=0.386;F=0.764,P=0.553）。结论：HFOV＋SIMV治疗新生儿胎粪吸入综合征是安全有效的。
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| 关 键 词： | 胎粪吸入综合征 高频振荡通气 同步间歇指令通气 新生儿 |
HFOV plus SIMV in the treatment of neonatal meconium aspiration syndrome |
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| WU Rong,HAN Liangrong,LI Na,ZHENG Guofang. HFOV plus SIMV in the treatment of neonatal meconium aspiration syndrome[J]. China Medical Herald, 2011, 8(28): 32-33,36 |
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| Authors: | WU Rong HAN Liangrong LI Na ZHENG Guofang |
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| Affiliation: | Department of Neonatology,Huai′an Maternity and Children Health Care Affiliated to the Medical College of Yangzhou University,Jiangsu Province,Huai′an 223002,China |
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| Abstract: | Objective: To observe the effect of HFOV plus SIMV in the treatment of neonates with meconium aspiration syndrome.Methods: 12 neonates with meconium aspiration syndrome were managed with HFOV plus SIMV.During HFOV plus SIMV,the minimum pressure strategy was performed,which was to achieve pulse oxygen saturation(SpO2) >0.9 and fraction of inspired oxygen(FiO2) <0.6 by gradually increasing mean airway pressure(MAP).Arterial partial pressure of carbon dioxide(PaCO2) was maintained in the normal range by adjust... |
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| Keywords: | Meconium aspiration syndrome High frequency oscillatory ventilation Synchronized intermittent mandatory ventilation Newborn |
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