| 银屑病的生物治疗研究进展 |
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| 引用本文： | 王育珏.银屑病的生物治疗研究进展[J].医学综述,2011,17(21):3201-3204. |
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| 作者姓名： | 王育珏 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院皮肤科,武汉,430022 |
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| 基金项目： | 国家自然科学基金，江西省卫生厅重大课题 |
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| 摘 要： | 近年来,随着在银屑病发病机制研究上取得的实质性进展,尤其是对分子免疫学基础的认识不断深入,出现了一系列新的靶向干预制剂———新型生物制剂。它们主要分为两类:抗细胞因子治疗和抗T细胞治疗,且主要用于治疗中-重度银屑病及银屑病型关节炎患者。虽然,生物制剂的短期疗效尚令人满意,但它们的长期疗效和安全性还有待进一步研究,以便更好地指导临床医师合理用药。
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| 关 键 词： | 银屑病 生物治疗 免疫学 |
Research Advances in the Biological Therapies for Psoriasis |
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| WANG Yu-jue.Research Advances in the Biological Therapies for Psoriasis[J].Medical Recapitulate,2011,17(21):3201-3204. |
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| Authors: | WANG Yu-jue |
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| Institution: | WANG Yu-jue1,TAO Juan1,YANG Jing1,LIU Ye-qiang2,TU Ya-ting1.(1.Department of Dermatology,Affiliated Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China,2.Department of Dermatology,Affiliated Hospital to Jiujiang University,Jiujiang 332000,China) |
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| Abstract: | Substantial advances being made in the pathogenesis of psoriasis these years,especially in the molecular and immunologic basis,had led to new agents that target these specific steps.This review was intend to introduce the new therapeutic approach that was mainly classified as T cell inhibitors and anti-cytokine agents in the management of moderate-to-severe psoriasis and psoriatic arthritis.Besides the satisfied short-term efficacy,the long-term efficacy and safety of these agents should be further studied ... |
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| Keywords: | Psoriasis Biological Therapy Immunology |
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