| HIF-1及相关信号通道在糖尿病视网膜病变中的研究进展 |
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| 引用本文： | 曹海静.HIF-1及相关信号通道在糖尿病视网膜病变中的研究进展[J].医学综述,2011,17(21):3207-3210. |
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| 作者姓名： | 曹海静 |
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| 作者单位： | 上海交通大学医学院附属第三人民医院眼科,上海,201900 |
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| 基金项目： | 中国上海市科学技术委员会自然科学基金 |
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| 摘 要： | 糖尿病视网膜病变(DR)是最常见的糖尿病微血管并发症,早期即出现视网膜缺血缺氧,进而导致一系列细胞因子紊乱,局部内环境失衡。而低氧诱导因子(HIF-1)与细胞内的缺氧反应密切相关,在DR早期多条信号通道通过调控HIF-1活性提高血管内皮细胞生长因子(VEGF)的表达,其与DR新生血管的形成有直接关系。理论上,干预信号通道中任何一种激酶都有可能阻止DR的发展。因此,参与信号通道的各级分子都有可能成为治疗DR的潜在靶目标。
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| 关 键 词： | 糖尿病视网膜病变 低氧诱导因子 信号通道 血管内皮细胞生长因子 |
Progress of Hypoxia-inducible Factor-1 Mediated Dominant Signaling Pathways in Diabetic Retinopathy |
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| CAO Hai-jing.Progress of Hypoxia-inducible Factor-1 Mediated Dominant Signaling Pathways in Diabetic Retinopathy[J].Medical Recapitulate,2011,17(21):3207-3210. |
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| Authors: | CAO Hai-jing |
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| Institution: | .(Department of Ophthalmology,NO.3 People′s Hospital Affiliated to School of Medicine of Shanghai Jiaotong University,Shanghai 201900,China) |
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| Abstract: | Diabetic retinopathy(DR)is the most common microvascular complication of diabetes mellitus.Ischemia and hypoxia in early diabetic retinopathy result in a series of cytokines disorders and local inner environment imbalances.Hypoxia-inducible factor-1(HIF-1)is closely related to intracellular anoxia,many signal pathways may modulate the activation of HIF-1 which can promote the vascular endothelial growth factor expression of early DR.It directly related to neovascularization of DR.In theory,any intervention ... |
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| Keywords: | Diabetic retinopathy Hypoxia-inducible factor-1 Signal pathways Vascular endothelial growth factor |
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