| 特发性肌炎与HLA基因的相关性研究进展 |
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| 引用本文： | 思远. 特发性肌炎与HLA基因的相关性研究进展[J]. 医学综述, 2011, 17(20): 3071-3073 |
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| 作者姓名： | 思远 |
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| 作者单位： | 广西医科大学第一附属医院皮肤科,南宁,530021 |
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| 摘 要： | 特发性肌炎(IIM)是以肌肉炎症为特征的罕见的自身免疫病及结缔组织病,包括皮肌炎、多发性肌炎、包涵体肌炎及儿童皮肌炎,此类疾病常与人类白细胞抗原(HLA)系统相关。HLA-Ⅱ类基因HLA-DRB1*0301和与它连锁的等位基因DQA1*0501以及单体型AH8.1已被许多研究证实是IIM的主要遗传危险因素,在白种人中表达最为显著。相同HLA等位基因在不同种族及表型中可为IIM遗传危险因素或保护因素。现就HLA等位基因与IIM的相关性进行综述。
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| 关 键 词： | 特发性肌炎 人类白细胞抗原 自身抗体 |
Update on the Correlation of HLA Allele and Idiopathic Inflammatory Myopathy |
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| SI Yuan. Update on the Correlation of HLA Allele and Idiopathic Inflammatory Myopathy[J]. Medical Recapitulate, 2011, 17(20): 3071-3073 |
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| Authors: | SI Yuan |
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| Affiliation: | SI Yuan,YAN Yu-lin.(Department of Dermatology,First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Idiopathic inflammatory myopathy(IIM),including dermatomyositis,polymyositis,inclusion body myositis,and juvenile dermatomoyositis,is a rare autoimmune and connective tissue diseases characterized by muscle inflammatory.These diseases are commonly associated with human leucocyte antigen(HLA)alleles.Studies have suggested an association of HLA-DRB1*0301 and HLA-DQA1*0501 are risk factors in adult and juvenile IIM.The same HLA alleles are risk or protective factors among various ethnic and different phenotype... |
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| Keywords: | Idiopathic inflammatory myopathy Human leukocyte antigen Autoantibodies |
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