P16INK4A与MIB-1在宫颈癌及宫颈癌前病变中的表达

目的：探讨P16INK4A与MIB-1在宫颈癌及宫颈癌前病变中的表达情况。方法：采用免疫组织化学方法检测P16INK4A与MIB-1在63例宫颈组织及38例宫颈涂片中的表达。结果：P16在正常宫颈上皮中均无表达。随着宫颈病变级别的增高，其阳性表达率逐渐增大，其中，宫颈癌中P16的表达增强明显。MIB-1随着宫颈病变级别的增高，表达增强，其中，宫颈癌中MIB-1的表达增强明显。在宫颈病变组织中，随着P16阳性表达率的增大，MIB-1表达也相应增高，具有相关性。结论：宫颈上皮内病变中P16及MIB-1过表达，提示两者可以作为宫颈病变的诊断标志物。在宫颈病变及宫颈癌的确切诊断中，P16及MIB-1可以作为诊断依据之-。

The expression of P16 INK4A and MIB-1 in cervical cancer and cervical cancer lesion before

Objective： To evaluate the expression of P16 INK4A and MIB-t in cervical cancer and cervical cancer lesion before. Methods： Immunohistochemistry methods were used to detect the expression of P16 INK4A and MIB-1 in 63 cases of cervical tissue and 38 cases of cerical smear. Results： No positive staining of PI6 was observed in the normal cervical epithelium. With increasing severity of cervical intraepithelial neoplasias （CIN）, the P16 expression increased progressively, significant up-regnlation of P16 was observed in carcinoma cervix. MIB-1 was observed with increasing severity of CIN, and significant overexpression of MIB-1 was observed in carcinoma cervix. The expression of MIB-1 was increased with consistendy increasing of P16, there was a correlation between P16 and MIB-1 in cervical lesions organization. Conclusion： The overexpression of P16 and MIB-1 demonstrates that they can be used as a diagnostic marker for cervical lesions. Therefore, in the exact diagnosis of cervical lesions and cervical cancer, P16 and MIB-1 markers can be used as one of the diagnostic bases.