马来酸桂哌齐特联合脑蛋白水解物治疗老年慢性脑动脉供血不足的疗效观察

目的：探讨马来酸桂哌齐特联合脑蛋白水解物治疗老年慢性脑动脉供血不足（CCC!）的疗效。方法：回顾性分析2004年1月～2010年12月于我院住院的80例慢性脑供血不足患者的临床资料，随机分为马来酸桂哌齐特＋脑蛋白水解物组和川芎嗪组，每组各40例。评价两组治疗效果和治疗前后平均血流速度（Vm）。结果：马来酸桂哌齐特＋脑蛋白水解物组缓解头昏、头痛症状的总有效率分别为92．5％和82．5％，川芎嗪组为72．5％和70．O％，两组比较差异均有统计学意义（均P〈0．05）。马来酸桂哌齐特±脑蛋白水解物组治疗后经颅多谱勒超声（TCD）检查高流速型CCCI患者双侧大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）及基底动脉（SA）的平均血流速度为（75±10）cm／s、（62±3）cm／s、（52±9）cm/s、（42±6）cm／s，低流速型CCCI患者MCA的平均血流速度为（65±10）cm／s，与川芎嗪组治疗后比较（88±8）cm／s、（69±5）cm／s、（61±11）cm／s、（56±9）cm/s、（54±11）cm／s]，差异均有统计学意义（均P〈0．05）。结论：马来酸桂哌齐特注射液与脑蛋白水解物联合治疗CCCI的临床症状效果较川芎嗪好。

Efficacy observation of Cinepazide Maleate combined with Cerebroprotein Hydrolysate in the treatment of senile chronic cerebral circulation insufficiency

Objective： To investigate curative effect of Cinepazide Maleate combined with Cerebroprotein Hydrolysate in the treament of senile chronic cerebral arterial insufficiency （CCCI）. Methods： Retrospective analysis was used. 80 cases of patients with chronic cerebral insufficiency from January 2004 to December 2010 in our hospital were randomly divided into Cinepazide Maleate＋Cerebroprotein Hydrolysate group and TMP group, 40 cases in each group. Curative effect and the mean blood flow velocity （Vm） before and after treatment were evaluated. Results： The total effective rate of relief dizziness and headache symptoms was 92.5% and 82.5% in Maleate Cinepazide＋Cerebroprotein Hydrolysate group, in TMPgroup was 72.5% and 70.0%, the difference was statistically significant （all P〈0.05）. The mean blood flow velocity of MCA, ACA, PCA, BA in patients with high flow velocity were （75±10） cm/s, （62＋3） cm/s, （52＋9） cm/s, （42±6） em/s and the MCA was （65＋10） cm/s in patients with low flow velocity after treatment in Cinepaside Maleate＋Cerebroprotein Hydrolysate group, compared with TMP group （88±8）, （69±5）, （61±11）, （56±9）, （54±11） cm/s], the difference was statistically significant （all P〈 0.05）. Conclusion： Curative effect of Cinepazide Maleate injection combined with Cerebroprotein Hydrolysate in the treament of chronic cerebral circulation insufficiency is better than TMP.